肠道微生物对自闭症谱系障碍症状的调节。

Gut Microbial Regulation of Autism Spectrum Disorder Symptoms.

机构信息

Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA; UCSF Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, CA, USA.

出版信息

Trends Endocrinol Metab. 2020 Nov;31(11):809-811. doi: 10.1016/j.tem.2020.09.001. Epub 2020 Sep 21.

DOI:10.1016/j.tem.2020.09.001

PMID:32972817

Abstract

Relationships between gut microbiome perturbation and autism spectrum disorder (ASD) have been observed in several human studies, but the functional implications and molecular mechanisms by which microbes may influence disease symptomology remain enigmatic. A recently published study by Sharon et al. offers evidence that the gut microbiome has a causative role in ASD and highlights the importance of early-life gut microbial metabolites in shaping mammalian behavior.

摘要

在几项人类研究中观察到肠道微生物组的扰动与自闭症谱系障碍（ASD）之间存在关系，但微生物可能影响疾病症状的功能意义和分子机制仍然是个谜。Sharon 等人最近发表的一项研究提供了肠道微生物组在 ASD 中起因果作用的证据，并强调了早期生活中肠道微生物代谢产物在塑造哺乳动物行为方面的重要性。