Pulendran Bali, Davis Mark M
Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
Department of Pathology, Stanford University, Stanford, CA 94305, USA.
Science. 2020 Sep 25;369(6511). doi: 10.1126/science.aay4014.
Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.
尽管有效疫苗的研发已使无数人免受传染病侵害，但人类免疫系统的基本运作十分复杂，需要借助诸如近交系小鼠等动物模型来确定免疫机制。最近，人们开发了新的策略和技术，以前所未有的精度直接探索人类免疫系统。我们将讨论这些方法如何推动我们对人类免疫学的机制理解，并促进针对感染、自身免疫性疾病和癌症的疫苗及治疗方法的开发。
