Pat Jackson J, Iqbal Muhammad Rafaih, Wright Christopher
Clinical Radiology, Southend University Hospital NHS Foundation Trust, Southend-on-Sea, UK.
Colorectal Surgery, Princess Alexandra Hospital, Harlow, UK.
J Surg Case Rep. 2020 Sep 19;2020(9):rjaa306. doi: 10.1093/jscr/rjaa306. eCollection 2020 Sep.
Neuroendocrine neoplasms are rare malignancies, more so when cancerous metastasis occurs without a known primary source. Here we discuss a case of an ulcerative colitis sufferer, 43-year-old lady presented with what was thought to be a flare up. Situation deteriorated and was taken to theatre to find a significantly ischaemic colon, secondary to extensive venous thrombosis. The ischaemic bowel was resected alongside with what was thought to be a large, reactive lymph node. To our surprise, the resected lymph node returned with evidence of neuroendocrine neoplastic metastasis. Multiple laboratory and imaging investigations were performed in hope to identify the primary source. A second metastatic lymph node was identified and subsequently resected but the primary remains elusive. Currently, there are no visible evidences of active disease.
神经内分泌肿瘤是罕见的恶性肿瘤,当发生癌转移且原发灶不明时更为罕见。在此,我们讨论一例溃疡性结肠炎患者,一名43岁女性,最初表现为病情发作。病情恶化后被送往手术室,发现结肠严重缺血,继发于广泛的静脉血栓形成。缺血肠段连同一个被认为是肿大的反应性淋巴结一起被切除。令我们惊讶的是,切除的淋巴结病理显示为神经内分泌肿瘤转移。进行了多项实验室检查和影像学检查,希望找到原发灶。又发现并切除了一个转移性淋巴结,但原发灶仍未明确。目前,没有活动性疾病的明显证据。