Itzkowitz Steven H, Present Daniel H
Division of Gastroenterology, Department of Medicine, The Mount Sinai School of Medicine, New York, New York, USA.
Inflamm Bowel Dis. 2005 Mar;11(3):314-21. doi: 10.1097/01.mib.0000160811.76729.d5.
The idiopathic inflammatory bowel diseases, ulcerative colitis and Crohn's colitis, are associated with an increased risk for developing colorectal cancer. To reduce colorectal cancer mortality in inflammatory bowel disease, most patients and their physicians choose to follow a program of surveillance colonoscopy in an attempt to detect early neoplastic lesions at a curable stage. Colectomy is typically reserved for patients whose biopsy findings are indicative of heightened cancer risk based on interpretation by pathologists. Despite the absence of prospective controlled clinical trials to formally evaluate the benefits, risks, and costs of this approach, enough circumstantial evidence has accrued to warrant its widespread adoption in practice. Nevertheless, no standardized guidelines have yet been set forth to guide the gastroenterologist in performing surveillance. A panel of international experts was assembled to develop consensus recommendations for the performance of surveillance. The findings are presented herein.
特发性炎症性肠病,即溃疡性结肠炎和克罗恩结肠炎,与患结直肠癌的风险增加相关。为降低炎症性肠病患者的结直肠癌死亡率,大多数患者及其医生选择遵循监测性结肠镜检查方案,试图在可治愈阶段检测出早期肿瘤性病变。结肠切除术通常适用于活检结果经病理学家解读表明癌症风险增加的患者。尽管缺乏前瞻性对照临床试验来正式评估这种方法的益处、风险和成本,但已有足够的间接证据支持其在实践中的广泛应用。然而,尚未制定标准化指南来指导胃肠病学家进行监测。为此组建了一个国际专家小组,以制定监测实施的共识性建议。现将研究结果公布如下。