Nyayanit Dimpal A, Sahay Rima R, Sakpal Gajanan N, Shete Anita M, Chaubal Gouri C, Sarkale Prasad, Srivastava Rashi, Mohandas Sreelekshmy, Yadav Pragya D
ICMR-National Institute of Virology, Pune, Maharashtra, India.
Access Microbiol. 2019 Jul 26;1(6):e000047. doi: 10.1099/acmi.0.000047. eCollection 2019.
Human herpes simplex virus (HSV)-1 infection is acquired in childhood and persists throughout a person's lifetime. Here, we present two cases from India; one showing symptoms of postpartum haemorrhage with disseminated intravascular coagulation, and the second one showing signs of acute encephalitis syndrome. The aetiological agent in both cases was identified as HSV-1 using the PCR method. The next-generation sequencing method retrieved ~97 % of the viral genome from the isolates of the clinical samples. The phylogenetic analysis of the retrieved genomes revealed that they belong to clade II of HSV-1. This study identifies a few sequence variations in the glycoprotein region of HSV-1 during two different clinical manifestations. There are a couple of papers that analyse variations in the glycoprotein region of clinical samples. Further, this study also highlights the importance of considering HSV-1 during differential diagnosis when analysing the nosocomial infection.
人单纯疱疹病毒1型（HSV-1）感染在儿童期获得，并在人的一生中持续存在。在此，我们展示来自印度的两个病例；一个表现为产后出血伴弥散性血管内凝血症状，另一个表现为急性脑炎综合征体征。使用聚合酶链反应（PCR）方法在这两个病例中均鉴定出病原体为HSV-1。下一代测序方法从临床样本分离物中检索到约97%的病毒基因组。对检索到的基因组进行系统发育分析表明，它们属于HSV-1的进化枝II。本研究确定了HSV-1糖蛋白区域在两种不同临床表现期间的一些序列变异。有几篇论文分析了临床样本糖蛋白区域的变异。此外，本研究还强调了在分析医院感染进行鉴别诊断时考虑HSV-1的重要性。
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