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用氯牛磺酸、溴牛磺酸和溴胺T成功治疗一种独特的慢性多菌性头皮感染。

Successful treatment of a unique chronic multi-bacterial scalp infection with -chlorotaurine, -bromotaurine and bromamine T.

作者信息

Kyriakopoulos Anthony M, Nagl Markus, Orth-Höller Dorothea, Marcinkiewicz Janusz, Baliou Stella, Zoumbourlis Vassilis

机构信息

Nasco AD Biotechnology Laboratory, 11 Sachtouri Str., Piraeus 18536, Greece.

Department of Hygiene, Microbiology and Social Medicine, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

Access Microbiol. 2020 Apr 24;2(7):acmi000126. doi: 10.1099/acmi.0.000126. eCollection 2020.

Abstract

Microbial species can act in synergy to circumvent environmental stress conditions and survive. In addition, biofilms are a serious public-health issue globally and constitute a clinical emergency. Infection persistence, increased morbidity and mortality, and antibiotic resistance are consequences of poly-microbial synergy. Due to inherited complexity and synergy between numerous species, newer antimicrobial agents of increased efficacy and tolerability are needed. In this unique medical case, a chronic (9 year) multi-bacterial scalp infection was differentially diagnosed from other inflammatory skin disorders by prolonged microbiological culture. The bacterial species found seem to have caused lesions of visible biofilm not documented previously in the medical literature. This complicated infection was treated successfully and rapidly with the combined topical application of the active halogen compounds -chlorotaurine, -bromotaurine and bromamine T, which is in contrast to the previous failed systemic and topical therapeutic approaches. This study strengthens the case for the use of active halogen compounds against multi-bacterial infections of the skin in the future, without the occurrence of resistance.

摘要

微生物物种可以协同作用以规避环境压力条件并存活下来。此外,生物膜在全球范围内是一个严重的公共卫生问题,构成临床急症。感染持续存在、发病率和死亡率增加以及抗生素耐药性是多种微生物协同作用的后果。由于众多物种之间存在固有的复杂性和协同作用,因此需要疗效更高、耐受性更好的新型抗菌药物。在这个独特的医疗案例中,通过长时间的微生物培养,将一例慢性(9年)多细菌头皮感染与其他炎症性皮肤病进行了鉴别诊断。所发现的细菌物种似乎导致了可见生物膜病变,这在医学文献中此前未有记载。与之前失败的全身和局部治疗方法形成对比的是,通过联合局部应用活性卤素化合物——氯牛磺酸、溴牛磺酸和溴胺T,这种复杂感染得到了成功且迅速的治疗。这项研究进一步证明了未来使用活性卤素化合物治疗皮肤多细菌感染的合理性,且不会产生耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de5d/7497830/e0d3dfe2d294/acmi-2-126-g001.jpg

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