Division of Cardiology, Osaka Rosai Hospital, Sakai.
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Coron Artery Dis. 2021 Mar 1;32(2):91-95. doi: 10.1097/MCA.0000000000000971.
The difference of chronic neointimal conditions of biodegradable polymer-coated and durable polymer-coated drug-eluting stent have not been well investigated.
We aimed to compare the angioscopic findings among SYNERGY biodegradable polymer-coated everolimus-eluting stent (BP-EES), ULTIMASTER biodegradable polymer-coated sirolimus-eluting stent (BP-SES), and XIENCE Alpine durable polymer-coated everolimus-eluting stent (DP-EES) 8 months after stent implantation.
Patients who underwent implantation of BP-EES (n = 30), BP-SES (n = 26), or DP-EES (n = 21) in Osaka Rosai Hospital from December 2015 to April 2017 were retrospectively enrolled. Coronary angioscopic evaluation including dominant grade of neointimal coverage (NIC) over the stent, maximum yellow plaque grade, and existence of red thrombi were performed 8 months after stent implantation. The incidence of major adverse cardiac events (MACE) including cardiac death, nonfatal myocardial infarction, and target vessel revascularization were assessed 1 year after coronary angioscopic evaluation among the three groups.
The patient and lesion characteristics were similar among the three groups. Dominant grade of NIC and maximum yellow plaque grade were not significantly different among BP-EES, BP-SES, and DP-EES groups [mean ± SD, 1.50 ± 0.73, 1.58 ± 0.64, and 1.33 ± 0.48 (P = 0.38) and 0.83 ± 0.59, 0.81 ± 0.75, and 0.95 ± 0.38 (P = 0.68), respectively]. The existence of red thrombi was similar among the three groups [20, 12, and 19% (P = 0.67)]. There was no significant difference in the MACE 1 year after coronary angioscopic evaluation among the three groups [0, 8, and 0% (P = 0.13)].
Coronary angioscopic findings revealed that BP-EES, BP-SES, and DP-EES produced similar favorable NIC 8 months after stent implantation.
生物可降解聚合物涂层和耐用聚合物涂层药物洗脱支架的慢性新生内膜条件差异尚未得到充分研究。
我们旨在比较 SYNERGY 生物可降解聚合物涂层依维莫司洗脱支架（BP-EES）、ULTIMASTER 生物可降解聚合物涂层西罗莫司洗脱支架（BP-SES）和 XIENCE Alpine 耐用聚合物涂层依维莫司洗脱支架（DP-EES）在支架植入 8 个月后的血管镜检查结果。
回顾性纳入 2015 年 12 月至 2017 年 4 月在大阪 Rosai 医院植入 BP-EES（n = 30）、BP-SES（n = 26）或 DP-EES（n = 21）的患者。支架植入后 8 个月进行包括支架上新生内膜覆盖主导等级（NIC）、最大黄色斑块等级和红色血栓存在的冠状动脉血管镜检查评估。在冠状动脉血管镜检查评估后的 1 年中，评估三组之间的主要不良心脏事件（MACE）的发生率，包括心脏死亡、非致死性心肌梗死和靶血管血运重建。
三组患者和病变特征相似。BP-EES、BP-SES 和 DP-EES 组的 NIC 主导等级和最大黄色斑块等级无显著差异[平均 ± SD，1.50 ± 0.73、1.58 ± 0.64 和 1.33 ± 0.48（P = 0.38）和 0.83 ± 0.59、0.81 ± 0.75 和 0.95 ± 0.38（P = 0.68）]。三组之间红色血栓的存在相似[20%、12%和 19%（P = 0.67）]。三组在冠状动脉血管镜检查评估后 1 年的 MACE 无显著差异[0%、8%和 0%（P = 0.13）]。
血管镜检查结果显示，BP-EES、BP-SES 和 DP-EES 在支架植入后 8 个月产生了相似的良好 NIC。
