Gore M E, Hills C A, Siddik Z H, Sloane J P, Winkley A R, Smith I E, Millar J L
Eur J Cancer Clin Oncol. 1987 Jan;23(1):75-80. doi: 10.1016/0277-5379(87)90422-6.
A dose of 170 mg/kg of carboplatin is lethal in mice, death occurring through bone marrow failure. This lethality can be avoided by giving the animals 200 mg/kg cyclophosphamide 1 or 2 days before this dose of carboplatin. The improved normal tissue tolerance cannot be explained by altered pharmacokinetics of carboplatin. Increased survival appears to be associated with a more rapid regeneration of the haemopoietic stem cells. Tumour tissue is not protected in the same way and thus a therapeutic gain can be achieved using this protocol.
卡铂剂量为170mg/kg对小鼠具有致死性，死亡是由骨髓衰竭所致。在给予该剂量卡铂前1或2天给动物注射200mg/kg环磷酰胺，可避免这种致死性。正常组织耐受性的改善无法用卡铂药代动力学的改变来解释。生存率的提高似乎与造血干细胞更快的再生有关。肿瘤组织不会以同样的方式得到保护，因此使用该方案可实现治疗效果的提升。
