Clinic of Clinical Services, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Clinic of Clinical Services, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Early Hum Dev. 2020 Dec;151:105171. doi: 10.1016/j.earlhumdev.2020.105171. Epub 2020 Sep 19.
Exposure of alcohol and/or other addictive drugs in pregnancy is a documented risk factor for later neurological impairment.
The aim of the study was to determine whether infants suffering from prenatal exposure to addictive drugs and alcohol develop an abnormal motor behaviour at three to four months of age.
Controlled cohort study of infants exposed to alcohol and/or other addictive drugs in pregnancy who were recruited from a hospital follow-up programme. The control group consisted of healthy, unexposed infants.
The study group of 108 infants exposed to alcohol and/or addictive drugs in pregnancy were enrolled based on referrals from primary health care. The control group included 106 infants who had not been exposed to the aforementioned substances.
We assessed the general movements (Prechtl's General-Movement-Assessment, GMA), the motor repertoire (Assessment-of-Motor-Repertoire, AMR), and the Alberta-Infant Motor-Scale (AIMS) in all infants at three to four months of age.
None of the infants in either group had absent fidgety movements (FMs). In the study group 5(5%) had exaggerated FMs and 5(5%) had sporadic FMs; and 68(63%) infants in the study group displayed an abnormal movement character, compared to 23(22%) in the control group (p<0.001). On the AIMS, 46(44%) infants in the study group scored below the 10th percentile, compared to 2(3%) controls (p< 0.001).
The study describes an abnormal movement character of infants exposed to alcohol and/or addictive drugs in pregnancy when their motor repertoire was assessed at three to four months of age. The AIMS also showed negative effects on their motor behaviour.
孕期暴露于酒精和/或其他成瘾药物是日后神经发育受损的已知风险因素。
本研究旨在确定在妊娠期间暴露于成瘾药物和酒精的婴儿在三至四个月大时是否会出现异常运动行为。
对在妊娠期间暴露于酒精和/或成瘾药物的婴儿进行的一项对照队列研究，这些婴儿是从医院随访计划中招募的。对照组由健康、未暴露的婴儿组成。
根据初级保健机构的转介，本研究纳入了 108 名在妊娠期间暴露于酒精和/或成瘾药物的婴儿作为研究组。对照组包括 106 名未接触上述物质的婴儿。
我们在三至四个月大时评估所有婴儿的一般运动（Prechtl 总体运动评估，GMA）、运动模式（运动模式评估，AMR）和阿尔伯塔婴儿运动量表（AIMS）。
两组均无婴儿出现无精打采的运动（FM）缺失。在研究组中，有 5（5%）例婴儿出现夸张的 FM，5（5%）例婴儿出现偶发的 FM；68（63%）例研究组婴儿表现出异常的运动特征，而对照组为 23（22%）例（p<0.001）。在 AIMS 上，研究组有 46（44%）例婴儿得分低于第 10 百分位，而对照组有 2（3%）例（p<0.001）。
本研究描述了在妊娠期间暴露于酒精和/或成瘾药物的婴儿在三至四个月大时运动模式评估时出现的异常运动特征。AIMS 还显示了对他们运动行为的负面影响。
