INSERM, Centre de Recherche des Cordeliers (CRC), Sorbonne Université, Université de Paris, F-75006 Paris, France.
Equipe labellisée "Ligue Nationale Contre le Cancer", F-75013 Paris, France.
Cells. 2020 Sep 23;9(10):2152. doi: 10.3390/cells9102152.
Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in () genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent complexity that surrounds the functions and specificities of the highly modular BAF (BG1/BRM-associated factors) and PBAF (polybromo-associated BAF) complexes, including ARID1A/B or ARID2, is baffling. The involvement of the SWI/SNF complexes in diverse tissues and processes, and especially in the regulation of gene expression, multiplies the specific outcomes of specific gene alterations. A better understanding of the molecular consequences of specific mutations impairing chromatin remodelers is needed. In this review, we summarize what we know about the tumor-modulating properties of ARID2 in hepatocellular carcinoma.
染色质重塑因子在癌症中高度突变，包括肝细胞癌。这些突变经常发生在 () 基因中，这些基因编码 ATP 依赖的 SWI/SNF 重塑因子的亚基。高度模块化的 BAF（BG1/BRM 相关因子）和 PBAF（多溴相关 BAF）复合物的功能和特异性所围绕的日益普遍的复杂性，包括 ARID1A/B 或 ARID2，令人困惑。SWI/SNF 复合物在不同组织和过程中的参与，特别是在基因表达的调控中，使特定基因改变的特定结果倍增。需要更好地了解特定突变损害染色质重塑因子的分子后果。在这篇综述中，我们总结了我们对 ARID2 在肝细胞癌中的肿瘤调节特性的了解。
