血浆纤连蛋白缺乏大鼠体内内毒素作用增强。

Enhanced endotoxin effects in plasma fibronectin-deficient rats.

作者信息

Yoder M C, Kilpatrick-Smith L, Arbittier D, Douglas S D, Polin R A

出版信息

Infect Immun. 1987 Jul;55(7):1715-7. doi: 10.1128/iai.55.7.1715-1717.1987.

DOI:10.1128/iai.55.7.1715-1717.1987

PMID:3298066

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260583/

Abstract

Immunoreactive plasma fibronectin depletion has been associated with the presence of collagen-fibronectin complexes in patients after trauma and in animal models of traumatic and burn injuries. However, the role of plasma fibronectin in the development of sepsis after traumatic and burn injuries in patients is unknown. Treatment of patients and animals with purified human plasma fibronectin ameliorates some of the clinical and metabolic effects of systemic endotoxemia. We report that the induction of immunoreactive plasma fibronectin deficiency by gelatin infusion is associated with enhanced effects of intraperitoneal Escherichia coli endotoxin injection. We have observed a significant increase in the concentrations of ammonia in plasma of treated rats compared with those in control rats administered the same dose of endotoxin.

摘要

免疫反应性血浆纤连蛋白耗竭与创伤后患者以及创伤和烧伤动物模型中胶原-纤连蛋白复合物的存在有关。然而，血浆纤连蛋白在创伤和烧伤患者发生脓毒症过程中的作用尚不清楚。用纯化的人血浆纤连蛋白治疗患者和动物可改善全身内毒素血症的一些临床和代谢影响。我们报告，输注明胶诱导免疫反应性血浆纤连蛋白缺乏与腹腔注射大肠杆菌内毒素的作用增强有关。我们观察到，与给予相同剂量内毒素的对照大鼠相比，治疗组大鼠血浆中氨的浓度显著升高。