在免疫组织化学及肿瘤定位中，针对不同结肠肿瘤相关抗原的单克隆抗体的比较。
A comparison of monoclonal antibodies against distinct colon tumor-associated antigens in immunohistochemistry and in tumor localization.
作者信息
Pant K D, Zamora P O, Sass K S, Stewart T A, Valdez E F, O'Rourke A T, Shah V O
出版信息
Int J Rad Appl Instrum B. 1987;14(2):81-9. doi: 10.1016/0883-2897(87)90136-x.
Monoclonal antibodies to colon/ovary tumor antigen (COTA), carcinoembryonic antigen (CEA), colon-specific antigen (CSA), and colon-specific antigen "protein" (CSAp) were evaluated for specificity, reactivity with normal tissues, and tumor localizations using athymic rats bearing xenografted human colon tumors. Radioiodine labeled anti-CSA and anti-COTA retained immunoreactivity and effectively localized the tumors; anti-CSAp retained immunoreactivity, but localized less effectively; and anti-CEA lost most of its immunoreactivity and localized poorly. Of the antibodies tested, anti-COTA showed potential for human colorectal tumor radiolocalization.
利用携带人结肠肿瘤异种移植瘤的无胸腺大鼠，对结肠/卵巢肿瘤抗原（COTA）、癌胚抗原（CEA）、结肠特异性抗原（CSA）和结肠特异性抗原“蛋白”（CSAp）的单克隆抗体进行了特异性、与正常组织的反应性以及肿瘤定位评估。放射性碘标记的抗CSA和抗COTA保留了免疫反应性并有效定位了肿瘤；抗CSAp保留了免疫反应性，但定位效果较差；抗CEA失去了大部分免疫反应性且定位不佳。在所测试的抗体中，抗COTA显示出用于人类结直肠肿瘤放射性定位的潜力。
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