Akkanti Bindu, Salas De Armas Ismael A, Sachedina Ayaaz K, Sunny Jennifer M, Ahmed Mahmoud Samy, Kaur Avaleen, Dinh Kha T, Hussain Rahat, Kumar Sachin, Nathan Sriram, Jumean Marwan, Patel Manish K, Akay Mehmet H, Patel Jayeshkumar A, Witz Barbi, Zaki John, Banjac Igor, Janowiak Lisa, Gregoric Igor D, Kar Biswajit
Department of Critical Care, Pulmonary, and Sleep Medicine, and Department of Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas; Center for Advanced Heart Failure, Memorial Hermann Hospital Heart & Vascular Institute, Houston, Texas; Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas; and Department of Anesthesia, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
J Extra Corpor Technol. 2020 Sep;52(3):191-195. doi: 10.1182/ject-2000021.
Although extracorporeal membrane oxygenation (ECMO) has been used in many different populations, its use in pregnant or postpartum patients has not been widely studied. This article reviews the ECMO experience in this population at a large urban hospital. Electronic medical records for all pregnant or postpartum patients who required ECMO between 2012 and 2019 were retrospectively reviewed. Data on clinical characteristics, outcomes, and complications were gathered. Comparisons between survivors and nonsurvivors were completed. Ten postpartum patients were identified. The patients presented as follows: four with cardiac arrest, one with a massive pulmonary embolism, three with acute respiratory distress syndrome (ARDS), one with combined ARDS and cardiogenic shock, and one with suspected amniotic embolism. Survival to decannulation was 70%, and survival to discharge was 60%. When comparing survivors vs. nonsurvivors, ECMO survivors tended to have shorter support times vs. nonsurvivors. Otherwise, no differences were noted in age, mechanical ventilation time, or length of stay. Disseminated intravascular coagulation was a common phenomenon in this patient cohort. After initiation of ECMO, elevated serum lactate levels, lower systolic blood pressure, and acute renal failure were predictors of mortality. In a single institution at a large metroplex, we present data regarding the use of ECMO in postpartum patients. ECMO can be successfully used in selected postpartum patients with severe cardiac or respiratory dysfunction. Multidisciplinary collaboration on a regular basis will streamline the ECMO referral in a timely manner. Furthermore, larger studies are indicated to understand the utility of ECMO in larger cohorts.
尽管体外膜肺氧合(ECMO)已应用于许多不同人群,但其在孕妇或产后患者中的应用尚未得到广泛研究。本文回顾了一家大型城市医院在这一人群中应用ECMO的经验。对2012年至2019年间所有需要ECMO的孕妇或产后患者的电子病历进行了回顾性分析。收集了临床特征、结局和并发症的数据。完成了幸存者与非幸存者之间的比较。确定了10例产后患者。患者情况如下:4例心脏骤停,1例大面积肺栓塞,3例急性呼吸窘迫综合征(ARDS),1例ARDS合并心源性休克,1例疑似羊水栓塞。脱机生存率为70%,出院生存率为60%。在比较幸存者与非幸存者时,ECMO幸存者的支持时间往往比非幸存者短。此外,在年龄、机械通气时间或住院时间方面未发现差异。弥散性血管内凝血在该患者队列中是一种常见现象。启动ECMO后,血清乳酸水平升高、收缩压降低和急性肾衰竭是死亡的预测因素。在一个大城市的单一机构中,我们展示了关于在产后患者中使用ECMO的数据。ECMO可成功用于选定的伴有严重心脏或呼吸功能障碍的产后患者。定期进行多学科协作将及时简化ECMO转诊流程。此外,需要开展更大规模的研究以了解ECMO在更大队列中的效用。