Di Lorenzo Gaspare, Martucci Gennaro, Sciacca Sergio, Longo Rosalia, Pilato Michele, Arcadipane Antonio
Perfusion Service, Department of Anesthesia and Intensive Care, IRCCS-ISMETT, Palermo, Italy
Department of Anesthesia and Intensive Care, IRCCS-ISMETT, Palermo, Italy.
Perfusion. 2016 Oct;31(7):611-3. doi: 10.1177/0267659116644496. Epub 2016 Apr 7.
Pregnant women with mechanical prosthetic heart valves have an increased risk of thrombosis and valve malfunctioning. Surgery carries a high risk of mortality for the mother and the fetus. A strategy for effective anticoagulation is crucial for these patients because both oral anticoagulants and heparin are associated with high risks for the mother and the fetus. The treatment of a pregnant woman with thrombosis and valve malfunction is a challenge, even for multidisciplinary teams, as cardiac surgery carries considerable risks. We present a woman at her 33rd week of pregnancy affected by congestive cardiac decompensation due to mechanical mitral prosthesis dysfunction. Given the expanded indication for ECMO and the recent evidence of the procedure's increased safety, even in the peri-partum period, we centered the treatment on VA-ECMO initiation before a Cesarean section (C-section) to guarantee support during surgery and avoid excessive anticoagulation or hypoperfusion to the fetus and as a bridge to cardiac surgery two days later. The strategy resulted in a good outcome with no complications for the mother and the fetus and a reasonable length of stay.
患有机械人工心脏瓣膜的孕妇发生血栓形成和瓣膜功能障碍的风险增加。手术对母亲和胎儿都有很高的死亡风险。有效的抗凝策略对这些患者至关重要,因为口服抗凝剂和肝素对母亲和胎儿都有高风险。即使对于多学科团队来说,治疗患有血栓形成和瓣膜功能障碍的孕妇也是一项挑战,因为心脏手术风险很大。我们介绍一位怀孕33周的女性,因机械二尖瓣假体功能障碍而出现充血性心脏代偿失调。鉴于体外膜肺氧合(ECMO)的适应症扩大,以及最近该手术安全性提高的证据,即使在围产期也是如此,我们将治疗重点放在剖宫产(C -section)前启动静脉-动脉体外膜肺氧合(VA-ECMO)上,以确保手术期间的支持,避免对胎儿过度抗凝或灌注不足,并作为两天后心脏手术的桥梁。该策略取得了良好的效果,母亲和胎儿均无并发症,住院时间合理。