冷冻疗法联合玻璃体内注射贝伐单抗治疗血管增生性肿瘤后眼部黄斑裂孔的形成
Macular Hole Formation in Eye After Cryotherapy and Intravitreal Bevacizumab Treatment for Vasoproliferative Tumor.
作者信息
Sato Atsuko, Fukui Emi, Ohta Kouichi
机构信息
Department of Ophthalmology, Matsumoto Dental University, Shiojiri, Nagano, Japan.
出版信息
Int Med Case Rep J. 2020 Sep 14;13:419-423. doi: 10.2147/IMCRJ.S266986. eCollection 2020.
PURPOSE
To report a case of a full-thickness macular hole (MH) that developed after cryotherapy and intravitreal bevacizumab injection (IVB) to treat a retinal vasoproliferative tumor (VPT).
METHODS
Case report of a man with a retinal VPT.
RESULTS
A 64-year-old Japanese man complained of blurred vision in his right eye. At the initial examination, his best-corrected visual acuity (BCVA) was 20/25 in the right eye and 20/20 in the left eye. Ophthalmoscopy showed a VPT in the lower peripheral retina of the right eye. An exudative retinal detachment and hard exudates were seen around the tumor. Cryotherapy and intravitreal injections of bevacizumab (IVB) were performed. Although the exudative changes were reduced, a MH developed two months after the initial IVB treatment. He underwent 25-gauge pars plana vitrectomy, and the MH was closed. His postoperative BCVA was 20/32 and the VPT was inactive. The reduced BCVA was due to damage of the outer retinal layers.
CONCLUSION
Our findings indicate that cryotherapy and IVB are effective treatments for VPT although the possibility of developing a MH should be considered.
目的
报告1例视网膜血管增生性肿瘤（VPT）患者在接受冷冻疗法和玻璃体内注射贝伐单抗（IVB）治疗后发生全层黄斑裂孔（MH）的病例。
方法
1例视网膜VPT男性患者的病例报告。
结果
一名64岁日本男性因右眼视力模糊就诊。初诊时，其右眼最佳矫正视力（BCVA）为20/25，左眼为20/20。眼底检查显示右眼周边下部视网膜有一个VPT。肿瘤周围可见渗出性视网膜脱离和硬性渗出。进行了冷冻疗法和玻璃体内注射贝伐单抗（IVB）。尽管渗出性改变有所减轻，但在首次IVB治疗后两个月出现了MH。他接受了25G经平坦部玻璃体切除术，MH闭合。术后其BCVA为20/32，VPT静止。BCVA下降是由于视网膜外层受损。
结论
我们的研究结果表明，冷冻疗法和IVB是治疗VPT的有效方法，不过应考虑发生MH的可能性。
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