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预测老年髋部骨折患者术后肺炎风险的列线图

A Nomogram for Prediction of Postoperative Pneumonia Risk in Elderly Hip Fracture Patients.

作者信息

Xiang Guangheng, Dong Xiaoyu, Xu Tao, Feng Yongzeng, He Zili, Ke Chenrong, Xiao Jian, Weng Yi-Min

机构信息

Department of Orthopaedic, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, People's Republic of China.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, People's Republic of China.

出版信息

Risk Manag Healthc Policy. 2020 Sep 16;13:1603-1611. doi: 10.2147/RMHP.S270326. eCollection 2020.

Abstract

PURPOSE

Pneumonia is one of the common complications of hip fracture. This study aimed to evaluate the risk factors and apply a nomogram to predict postoperative pneumonia in elderly hip fracture patients.

MATERIALS AND METHODS

From August 2014 to October 2019, 1113 hip fracture patients who were older than 65 years and underwent surgical treatment in our hospital were subjects of this study. Univariate and multivariate Cox analyses were used to identify independent risk factors. A predictive nomogram model was built, and the discrimination and calibration were determined by receiver operating characteristic and calibration plot.

RESULTS

A total of 166 patients developed pneumonia after operation (14.91%, pneumonia group) while the remaining 947 patients did not (85.09%, non-pneumonia group). According to the results, body mass index (OR, 0.76, 95% CI, 0.70 to 0.84, P<0.001), serum albumin (OR, 0.86, 95% CI, 0.79 to 0.93, P<0.001), c-reactive protein (OR, 1.01, 95% CI, 1.00 to 1.92, P=0.011), functional status (OR, 2.94, 95% CI, 1.69 to 5.10, P<0.001) and time to surgery (OR, 4.56, 95% CI, 2.64 to 7.88, P<0.001) were identified as independent risk factors of pneumonia. The area under the curve value for postoperative pneumonia risk was 0.905, and the P-value of the Hosmer-Lemeshow calibration test was 0.529.

CONCLUSION

Our nomogram model can be used to predict the risk of pneumonia in elderly hip fractures after surgery and provide clinicians with guidance for better perioperative intervention to improve prognosis and reduce mortality.

摘要

目的

肺炎是髋部骨折常见的并发症之一。本研究旨在评估老年髋部骨折患者术后肺炎的危险因素,并应用列线图预测术后肺炎。

材料与方法

2014年8月至2019年10月,选取我院1113例年龄大于65岁且接受手术治疗的髋部骨折患者作为研究对象。采用单因素和多因素Cox分析确定独立危险因素。构建预测列线图模型,并通过受试者工作特征曲线和校准图确定其区分度和校准度。

结果

术后共有166例患者发生肺炎(14.91%,肺炎组),其余947例患者未发生肺炎(85.09%,非肺炎组)。结果显示,体重指数(OR,0.76,95%CI,0.70至0.84,P<0.001)、血清白蛋白(OR,0.86,95%CI,0.79至0.93,P<0.001)、C反应蛋白(OR,1.01,95%CI,1.00至1.92,P=0.011)、功能状态(OR,2.94,95%CI,1.69至5.10,P<0.001)和手术时间(OR,4.56,95%CI,2.64至7.88,P<0.001)被确定为肺炎的独立危险因素。术后肺炎风险的曲线下面积值为0.905,Hosmer-Lemeshow校准检验的P值为0.529。

结论

我们的列线图模型可用于预测老年髋部骨折患者术后肺炎的风险,并为临床医生提供指导,以便更好地进行围手术期干预,改善预后,降低死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d0b/7502327/ddf0da777547/RMHP-13-1603-g0001.jpg

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