Ying Zhenguang, Yang Jing, Li Wei, Wang Xia, Zhu Zeyao, Jiang Weipeng, Li Chunman, Sha Ou
Department of Anatomy, Histology and Developmental Biology, School of Basic Medical Sciences, Shenzhen University Health Science Centre, Shenzhen, China.
School of Dentistry, Shenzhen University Health Science Centre, Shenzhen, China.
Front Cell Dev Biol. 2020 Aug 28;8:866. doi: 10.3389/fcell.2020.00866. eCollection 2020.
Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expressed in a variety of cancers. Astrin promotes the development of cancer by participating in various molecular pathways and is considered as a potential prognostic and survival predictor.
Astrin是一种与纺锤体相关的蛋白质，被发现与有丝分裂纺锤体的形成和维持密切相关。它与其他纺锤体相关蛋白相互作用，在维持动粒微管附着以及中心体完整性和促进中心粒复制方面发挥关键作用。此外，最近发现Astrin在多种癌症中异常高表达。Astrin通过参与各种分子途径促进癌症发展，被认为是一种潜在的预后和生存预测指标。
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