Xu Jiahui, Jin Bo, Zhang Lisan, Wang Shuang
Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China.
Department of Neurology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 Aug 25;49(4):425-430. doi: 10.3785/j.issn.1008-9292.2020.08.04.
Sleep-related hypermotor epilepsy (SHE), formerly known as nocturnal frontal epilepsy, is characterized by asymmetrical tonic or complex hypermotor seizures during sleep, with transient, frequent and clustering attack. The accurate incidence is not known but somehow low, which is estimated about 1.8/100 000. The differential diagnosis between SHE and parasomnias may be challenging due to possible similarities between the two sleep-related manifestations. In a majority of patients, the etiology is unknown. Identified etiologies are heterogeneous and structural abnormalities,which are involved in the severity and prognosis of SHE. In terms of treatment, it mainly includes pharmacological therapy and surgery. Carbamazepine seems to be the drug of choice in SHE patients, and epilepsy surgery provides excellent results in selected drug-resistant SHE cases. This review will focus on diagnosis, pathogenesis, treatment and prognosis of SHE, aiming to promote its early diagnosis and appropriate treatment.
睡眠相关性运动过多型癫痫（SHE），以前称为夜间额叶癫痫，其特征是睡眠期间出现不对称性强直或复杂的运动过多型发作，发作短暂、频繁且成簇。准确发病率尚不清楚，但总体较低，估计约为1.8/10万。由于这两种与睡眠相关的表现可能存在相似之处，SHE与睡眠障碍的鉴别诊断可能具有挑战性。大多数患者病因不明。已确定的病因多种多样，包括结构异常，这些因素与SHE的严重程度和预后有关。在治疗方面，主要包括药物治疗和手术治疗。卡马西平似乎是SHE患者的首选药物，癫痫手术在部分耐药性SHE病例中效果良好。本综述将聚焦于SHE的诊断、发病机制、治疗及预后，旨在促进其早期诊断和合理治疗。
