一种用于超灵敏检测肿瘤外泌体的三维多足 DNA walker。
A three-dimensional multipedal DNA walker for the ultrasensitive detection of tumor exosomes.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China.
出版信息
Chem Commun (Camb). 2020 Nov 4;56(85):12949-12952. doi: 10.1039/d0cc04360e. Epub 2020 Sep 28.
A three-dimensional (3D) multipedal DNA walker triggered by the specific recognition between aptamers and proteins was developed for ultrasensitive tumor exosome sensing. A detection limit of 1 particle μL was obtained with high selectivity. With the advantages of being simple, cost-effective and ultrasensitive, the biosensor offers potential for the early clinical diagnosis of tumors.
一种由适体与蛋白质之间的特异性识别触发的三维（3D）多足 DNA walker 被开发用于超灵敏肿瘤外泌体传感。该方法具有检测限低至 1 个粒子 μL、选择性高的优点。该生物传感器具有简单、经济高效和超灵敏的优点，为肿瘤的早期临床诊断提供了潜力。
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