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伴有急性运动功能障碍的黄韧带囊肿:文献综述与病例系列

Ligamentum Flavum Cyst With Acute Onset Motor Deficit: A Literature Review and Case Series.

作者信息

Kalidindi Kalyan Kumar Varma, Bhat Mohd Rafiq, Gupta Mayank, Mannem Abhishek, Chhabra Harvinder Singh

机构信息

Indian Spinal Injuries Centre, Vasant Kunj, New Delhi, India.

出版信息

Int J Spine Surg. 2020 Aug;14(4):544-551. doi: 10.14444/7072. Epub 2020 Jul 31.

DOI:10.14444/7072
PMID:32986576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7478069/
Abstract

BACKGROUND

Ligamentum flavum cysts have been rarely described in the literature and are one of the rare causes of neural compression and canal stenosis. Very few cases of their association with neurologic deficits are reported to date, and association with acute onset weakness is even rarer.

CLINICAL PRESENTATION

We report our experience with 3 cases of ligamentum flavum cyst that presented with acute onset weakness and also present a comprehensive literature review on lumbar ligamentum flavum cysts reported to date. All 3 patients had symptoms of severe neurogenic claudication and presented to us with acute onset of motor weakness in lower limbs. Ligamentum flavum cyst was located in the midline in 2 cases and laterally in 1 case. We performed excision of the cyst and decompression with fusion in 2 cases and decompression alone in 1 case. All 3 cases had significant improvement in their neurologic status postoperatively. Histopathological examination confirmed ligamentum flavum cyst in all 3 cases. We performed a PUBMED and EMBASE database search using the MeSH (Medical Subject Headings) terms "ligamentum flavum" and "cysts" for articles published to April 2019. We could identify 7 studies describing 20 cases of lumbar ligamentum flavum cysts with motor weakness in the literature. Only 1 case had been described with an acute onset of weakness.

CONCLUSIONS

Ligamentum flavum cysts should remain in the differential diagnosis of a patient who has symptoms of lumbar canal stenosis and presents with acute onset of neurological deficits. Such patients have a good improvement with surgery.

摘要

背景

黄韧带囊肿在文献中鲜有描述,是神经受压和椎管狭窄的罕见原因之一。迄今为止,很少有其与神经功能缺损相关的病例报道,与急性起病的肌无力相关的病例更是罕见。

临床表现

我们报告了3例表现为急性起病肌无力的黄韧带囊肿病例的经验,并对迄今为止报道的腰椎黄韧带囊肿进行了全面的文献综述。所有3例患者均有严重神经源性间歇性跛行症状,并以急性下肢运动无力就诊。黄韧带囊肿2例位于中线,1例位于侧方。我们对2例患者进行了囊肿切除及减压融合术,对1例患者仅进行了减压术。所有3例患者术后神经功能均有显著改善。组织病理学检查证实所有3例均为黄韧带囊肿。我们使用医学主题词(MeSH)“黄韧带”和“囊肿”在PUBMED和EMBASE数据库中检索截至2019年4月发表的文章。我们在文献中发现7项研究描述了20例伴有运动无力的腰椎黄韧带囊肿病例。仅有1例描述为急性起病的肌无力。

结论

对于有腰椎管狭窄症状且急性起病出现神经功能缺损的患者,黄韧带囊肿应保留在鉴别诊断中。此类患者手术治疗后改善良好。

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本文引用的文献

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Symptomatic Tuberculous Ligamentum Flavum Cyst Treated by Full Endoscopic Resection: Review with Technical Notes.全内镜下切除治疗症状性结核性黄韧带囊肿:附技术要点回顾
World Neurosurg. 2019 Feb;122:112-115. doi: 10.1016/j.wneu.2018.10.141. Epub 2018 Nov 1.
2
Ligamentum flavum cyst: An uncommon but recognizable and surgically correctable category of juxtafacet cyst.黄韧带囊肿:一种罕见但可识别且可通过手术矫正的关节突旁囊肿类型。
Radiol Case Rep. 2017 Oct 20;13(1):302-304. doi: 10.1016/j.radcr.2017.09.009. eCollection 2018 Feb.
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[Lumbar spinal canal stenosis complicated with lumbar ligamentum flavum cyst: a case report].[腰椎管狭窄症合并黄韧带囊肿1例报告]
Zhongguo Gu Shang. 2017 May 25;30(5):479-480. doi: 10.3969/j.issn.1003-0034.2017.05.017.
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Histopathology of synovial cysts of the spine.脊柱滑液囊肿的组织病理学。
Histopathology. 2018 May;72(6):923-929. doi: 10.1111/his.13465. Epub 2018 Mar 5.
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Midline Ligamentum Flavum Cyst of Lumbar Spine.腰椎黄韧带中线囊肿
World Neurosurg. 2018 Feb;110:284-287. doi: 10.1016/j.wneu.2017.11.075. Epub 2017 Nov 23.
6
Acute Bilateral Foot Drop as Presenting Symptom of Hemorrhagic Synovial Cyst of Lumbar Spine.急性双侧足下垂作为腰椎出血性滑膜囊肿的首发症状
World Neurosurg. 2017 Dec;108:999.e7-999.e9. doi: 10.1016/j.wneu.2017.09.098. Epub 2017 Sep 23.
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Haemorrhagic lumbar juxtafacet cyst with ligamentum flavum involvement.累及黄韧带的出血性腰椎关节突旁囊肿
Case Rep Orthop. 2014;2014:126067. doi: 10.1155/2014/126067. Epub 2014 Dec 14.
8
Ligamentum flavum cyst of lumbar spine: a case report and literature review.腰椎黄韧带囊肿:一例报告并文献复习
Korean J Spine. 2014 Mar;11(1):18-21. doi: 10.14245/kjs.2014.11.1.18. Epub 2014 Mar 31.
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Symptomatic ganglion cyst of ligamentum flavum as a late complication of lumbar fixation.黄韧带腱鞘囊肿作为腰椎固定术的晚期并发症出现症状。
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Recurrent hemorrhage of ligamentum flavum cyst: case report.黄韧带囊肿反复出血:病例报告。
Chin Med J (Engl). 2011 Dec;124(24):4361-3.