Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, Florida, USA,
Department of Oncologic Sciences and Pathology, University of South Florida, Tampa, Florida, USA,
Monogr Clin Cytol. 2020;26:34-41. doi: 10.1159/000455733. Epub 2020 Sep 28.
The pancreas is a retroperitoneal organ located in the duodenal loop with the posterior wall of the stomach overlying it and the left lobe of the liver lying anteriorly to it. Tissues from these organs, in addition to the lesion of interest within the pancreas, may be sampled during fine-needle aspiration (FNA) procedures. Therefore, it is important to recognize the cytology of normal benign components of the pancreas and potential contaminants in order to render a correct diagnosis and avoid pitfalls. Normal components of the pancreas include ductal epithelial cells, acinar cells, and islet cells. In addition to the normal pancreatic cells, it is not uncommon to encounter epithelial cells from the duodenal and gastric mucosa with endoscopic ultrasound-guided fine-needle aspiration. It is important to recognize these cells as benign and to distinguish them from a well-differentiated pancreatic adenocarcinoma. Besides these, mesothelial cells and hepatocytes and bile duct cells from the liver may be sampled as well. Here, the cytological features of normal components and contaminants are described in detail.
胰腺是一个位于十二指肠环内的腹膜后器官，其上方为胃后壁，前方为左肝叶。在细针抽吸（FNA）过程中，除了胰腺内感兴趣的病变外，还可能会采集这些器官的组织。因此，为了做出正确的诊断并避免陷阱，识别胰腺正常良性成分和潜在污染物的细胞学特征非常重要。胰腺的正常成分包括导管上皮细胞、腺泡细胞和胰岛细胞。除了正常的胰腺细胞外，在经内镜超声引导的细针抽吸时，也不罕见会遇到来自十二指肠和胃黏膜的上皮细胞。重要的是要将这些细胞识别为良性，并将其与分化良好的胰腺腺癌区分开来。除此之外，间皮细胞、肝细胞和来自肝脏的胆管细胞也可能被采集。在此，详细描述了正常成分和污染物的细胞学特征。
