Université de Lille, Université d'Artois, Université de Littoral Côte d'Opale, ULR 7369 - URePSSS-Unité de Recherche Pluridisciplinaire Sport Santé Société, Lille, France.
Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ontario; and Department of Molecular and Cellular Medicine, Faculty of Medicine, University of Ottawa, Ontario, Canada.
Nutr Rev. 2021 Jan 1;79(1):25-41. doi: 10.1093/nutrit/nuaa094.
Mitochondrial dysfunction is observed in a broad range of human diseases, including rare genetic disorders and complex acquired pathologies. For this reason, there is increasing interest in identifying safe and effective strategies to mitigate mitochondrial impairments. Natural compounds are widely used for multiple indications, and their broad healing properties suggest that several may improve mitochondrial function. This review focuses on (-)-epicatechin, a monomeric flavanol, and its effects on mitochondria. The review summarizes the available data on the effects of acute and chronic (-)-epicatechin supplementation on mitochondrial function, outlines the potential mechanisms involved in mitochondrial biogenesis induced by (-)-epicatechin supplementation and discusses some future therapeutic applications.
线粒体功能障碍在广泛的人类疾病中都有观察到，包括罕见的遗传疾病和复杂的后天病理。出于这个原因，人们越来越有兴趣寻找安全有效的策略来减轻线粒体损伤。天然化合物被广泛用于多种适应症，其广泛的治疗特性表明，其中一些可能改善线粒体功能。本综述重点关注（-）-表儿茶素，一种单体黄烷醇，及其对线粒体的影响。综述总结了关于急性和慢性（-）-表儿茶素补充对线粒体功能影响的现有数据，概述了（-）-表儿茶素补充诱导线粒体生物发生所涉及的潜在机制，并讨论了一些未来的治疗应用。
