Sirtuin 1 在衰老过程中在大鼠腹内侧和背内侧下丘脑核中的表达。
Sirtuin 1 Expression in the Rat Ventromedial and Dorsomedial Hypothalamic Nuclei during Ageing.
机构信息
Yaroslalv State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
出版信息
Bull Exp Biol Med. 2020 Sep;169(5):698-700. doi: 10.1007/s10517-020-04958-8. Epub 2020 Sep 28.
We studied the expression of sirtuin 1 (Sirt1) in the dorsomedial and ventromedial nuclei of the hypothalamus in young (2 months) and old (2 years) rats by immunohistochemical methods and Western blotting. In aged males and females, a decrease in Sirt1 expression in dorsomedial nucleus was observed. In ventromedial nucleus, the expression of Sirt1 did not change with age. The results confirm the hypothesis that aging is associated with a decrease in the content of sirtuins in the hypothalamic nuclei.
我们通过免疫组织化学方法和 Western blot 研究了年轻（2 个月）和老年（2 年）大鼠下丘脑背内侧核和腹内侧核中沉默调节蛋白 1（Sirt1）的表达。在老年雄性和雌性大鼠中，观察到背内侧核中 Sirt1 表达减少。在腹内侧核中，Sirt1 的表达随年龄变化而不改变。这些结果证实了衰老与下丘脑核中沉默调节蛋白含量减少有关的假设。
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