Uher T, Bohm A, Urban L, Tothova L, Bacharova L, Musil P, Kyselovic J, Michalek P, Vachalcova M, Olejnik P, Hatala R
Bratisl Lek Listy. 2020;121(7):484-487. doi: 10.4149/BLL_2020_079.
Previous studies showed an association between apelin and atrial fibrillation (AF). The aim of this study was to analyse the effect of pulmonary vein isolation (PVI) in patients with paroxysmal AF on plasmatic apelin concentrations.
Nine consecutive patients (aged from 43 to 69 years, 3 females and 6 males) with documented paroxysmal atrial fibrillation and implanted loop recorders (ILR) for continuous ECG monitoring were included in this study. All the patients underwent a radiofrequency catheter ablation with PVI.
The plasmatic concentration of apelin increased after PVI. The average plasmatic concentration of apelin before PVI was 0.299 ng/ml (±0.16), 3 months after PVI 0.462 ng/ml (±0.10) and 9 months after PVI 0.565 ng/ml (±0.146). There was an increase in the concentration of apelin 3 months and 9 months after the PVI by 0.163 ng/ml (p=0.07) and by 0.266 ng/ml (p=0.01), respectively. The concentration of apelin inversely correlated with the AF burden (r=-0.44, p=0.03).
Our study showed a significant increase in apelin levels after the reduction of AF burden via PVI and an inverse correlation with AF burden. Apelin might be a promising marker of AF (Tab. 2, Fig. 2, Ref. 28).
先前的研究表明阿片肽与心房颤动（AF）之间存在关联。本研究的目的是分析阵发性房颤患者肺静脉隔离（PVI）对血浆阿片肽浓度的影响。
本研究纳入了9例连续的记录有阵发性房颤且植入了用于连续心电图监测的环行记录仪（ILR）的患者（年龄43至69岁，女性3例，男性6例）。所有患者均接受了PVI射频导管消融术。
PVI术后血浆阿片肽浓度升高。PVI术前阿片肽的平均血浆浓度为0.299 ng/ml（±0.16），PVI术后3个月为0.462 ng/ml（±0.10），术后9个月为0.565 ng/ml（±0.146）。PVI术后3个月和9个月阿片肽浓度分别升高了0.163 ng/ml（p = 0.07）和0.266 ng/ml（p = 0.01）。阿片肽浓度与房颤负荷呈负相关（r = -0.44，p = 0.03）。
我们的研究表明，通过PVI减轻房颤负荷后，阿片肽水平显著升高，且与房颤负荷呈负相关。阿片肽可能是一种有前景的房颤标志物（表2，图2，参考文献28）。
