School of Pharmaceutical Sciences, Guru Ghasidas Central University, Bilaspur-495 009 (C.G.), India.
Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda-151 001 (Punjab), India.
Curr Pharm Des. 2021;27(6):855-865. doi: 10.2174/1381612826666200929123715.
Being the second most frequent cancer, breast cancer is emerging worldwide with an alarming rate, specifically in post-menopausal women. Targeted drug delivery has been in the focus for the successful treatment of breast cancer by enhancing the drug delivery efficiency and reducing the systemic toxicity of drugs. Also, it eliminates the drawbacks associated with conventional chemotherapy, including neuropathy, memory loss, cardiotoxicity and low RBCs count. This review elaborates the polymeric nanoparticles based formulation approaches for selective and sustained delivery for effective cure of breast cancer. However, breast cancer, a life-threatening disease, is mostly caused because of estrogen, thus aromatase inhibitors and estrogen synthesis inhibitors could prevent chances of breast cancer. The disease is associated with drug resistance and some side effects, which could be easily eliminated by using novel therapeutic approaches. Aromatase inhibitors, when entrapped in nanoparticles, have shown sustained drug release, advocating themselves to be beneficial for the treatment of breast cancer.
乳腺癌是全球第二大常见癌症，发病率呈惊人的上升趋势，尤其是在绝经后妇女中。通过提高药物递送效率和降低药物的系统毒性，靶向药物递送已成为治疗乳腺癌的重点。此外，它还消除了与传统化疗相关的缺点，包括神经病变、记忆力减退、心脏毒性和低红细胞计数。本文综述了基于聚合物纳米粒子的制剂方法，用于选择性和持续的药物递送，以有效治疗乳腺癌。然而，乳腺癌作为一种危及生命的疾病，主要是由雌激素引起的，因此芳香酶抑制剂和雌激素合成抑制剂可以降低乳腺癌的发病几率。该疾病与药物耐药性和一些副作用有关，通过使用新型治疗方法可以很容易地消除这些副作用。将芳香酶抑制剂包封在纳米粒子中，可以实现药物的持续释放，有利于治疗乳腺癌。
