Department of Food and Nutrition, Kyungsung Universtiy, Busan, Korea.
Department of Food and Nutrition, Kyungsung Universtiy, Busan, Korea. Email:
Asia Pac J Clin Nutr. 2020;29(3):648-656. doi: 10.6133/apjcn.202009_29(3).0025.
There are many studies investigating nutritional factors that affect both sarcopenia and muscle formation. According to extensive research, protein has an essential role in muscle formation. More recently, vitamin D has emerged as an important factor that regulates muscle metabolism. However, studies and research of association between 25-Hydroxyvitamin D (25(OH)D) status and components of homeostasis model assessment of insulin resistance (HOMA-IR) in older are limited. Nineteen studies were found through a search of electronic databases and were subjected to a meta-analysis to investigate the differences in serum levels of 25(OH)D and HOMA-IR between patients with controls and sarcopenia. The random-effects standardized mean difference (SD) and 95% confidence interval (CI) were calculated as the effect size. Nineteen studies with 19,528 participants (5,081 with sarcopenia and 14,447 without) were analyzed. Sarcopenic participants had significantly lower serum levels of 25(OH)D (SD =1.163; 95% CI 0.514, 1.812; p<0.001; I2=99.652%) and HOMA-IR (SD=-2.040; 95% CI -3.376, -0.705; p<0.005; I2=99.837%) than controls. It has been reiterated that sarcopenia may be related serum levels of 25(OH)D and HOMA-IR. This relationship needs to be clarified by future longitudinal studies.
有许多研究探讨了影响肌少症和肌肉形成的营养因素。根据广泛的研究，蛋白质对肌肉形成起着至关重要的作用。最近，维生素 D 已成为调节肌肉代谢的重要因素。然而，关于 25-羟维生素 D（25（OH）D）状态与胰岛素抵抗评估的稳态模型评估（HOMA-IR）成分之间的关联的研究和研究有限。通过电子数据库搜索发现了 19 项研究，并进行了荟萃分析，以调查患者与对照组和肌少症患者之间血清 25（OH）D 和 HOMA-IR 水平的差异。计算随机效应标准化均数差（SD）和 95%置信区间（CI）作为效应大小。分析了 19 项研究，共 19528 名参与者（5081 名肌少症患者和 14447 名非肌少症患者）。肌少症患者的血清 25（OH）D（SD=1.163；95%CI 0.514，1.812；p<0.001；I2=99.652%）和 HOMA-IR（SD=-2.040；95%CI -3.376，-0.705；p<0.005；I2=99.837%）水平明显低于对照组。反复强调肌少症可能与血清 25（OH）D 和 HOMA-IR 水平有关。这种关系需要通过未来的纵向研究来阐明。
