Leonangeli Sebastian, Fraire Jazmín Azul, Loza Jorge Luis
Laboratorio de Neurofisiología, IMMF-INIMEC-CONICET-UNC.
Cátedra de Farmacología General, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba.
Rev Fac Cien Med Univ Nac Cordoba. 2020 Aug 21;77(3):211-213. doi: 10.31053/1853.0605.v77.n3.27857.
The anticonvulsant hypersensitivity syndrome is a rare adverse reaction in which the skin, lymph nodes and internal organs are affected. It is usually caused by classic anticonvulsants such as phenytoin, carbamazepine or phenobarbital.
Here we present the case of a 25-year-old woman from Córdoba, Argentina, who suffered a severe reaction to oxcarbazepine with a rash, lymphadenopathy, hepatitis and an unusual analytic. Clinical abnormalities were reversed after oxcarbazepine was terminated and treatment with diphenhydramine and dexamethasone was initiated.
DRESS syndrome is a hypersensitivity reaction that takes weeks to manifest, and is characterized by rash, leukocytosis with eosinophilia, adenopathies, liver involvement, and reactivation of the herpes virus 6, being more frequent in carbamazepine or phenytoin, and in rare cases to oxcarbazepine.
In general, this strong medicine is not taken into account as a cause of hypersensitivity, reports suggest that it could be related to cases similar to this one, and studies that are more targeted are required, due to the morbidity and mortality of the syndrome.
抗惊厥药物超敏反应综合征是一种罕见的不良反应，会影响皮肤、淋巴结和内脏器官。它通常由苯妥英钠、卡马西平或苯巴比妥等经典抗惊厥药物引起。
我们在此介绍一名来自阿根廷科尔多瓦的25岁女性病例，她对奥卡西平产生了严重反应，出现皮疹、淋巴结病、肝炎及异常的分析结果。停用奥卡西平并开始使用苯海拉明和地塞米松治疗后，临床异常情况得到逆转。
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征是一种需数周才会显现的超敏反应，其特征为皮疹、伴有嗜酸性粒细胞增多的白细胞增多、淋巴结病、肝脏受累以及疱疹病毒6激活，在卡马西平或苯妥英钠引发时更为常见，奥卡西平引发的情况较为罕见。
总体而言，这种强效药物通常不被视为超敏反应的病因，报告表明它可能与此类病例有关，鉴于该综合征的发病率和死亡率，需要开展更具针对性的研究。
