Sato K, Oguchi H, Hora K, Furukawa T, Furuta S, Shigematsu H, Yoshizawa S
Nephron. 1987;46(2):174-8. doi: 10.1159/000184336.
Idiopathic membranous nephropathy has been reported rarely to develop in genetic association with certain HLA antigens. This paper describes two male siblings presenting with nephrotic syndrome with histologically proven membranous nephropathy. The younger brother maintained a normal renal function with slight proteinuria during the 3 years of follow-up, but the older one experienced a rapid decline in renal function and had to be put on maintenance hemodialysis. No clinical evidence of contributory underlying disease such as malignancy or systemic lupus erythematosus could be found. HLA typing was carried out in the two patients and in members of their family. Several HLA antigens were found to be shared by the two patients. However, the HLA antigens which have been reported to be associated with idiopathic membranous nephropathy were not found in either of them.
特发性膜性肾病极少有与某些人类白细胞抗原（HLA）呈遗传关联而发病的报道。本文描述了两名患有肾病综合征且经组织学证实为膜性肾病的男性同胞。弟弟在3年的随访期间肾功能正常，仅有轻度蛋白尿，但哥哥肾功能迅速下降，不得不接受维持性血液透析。未发现诸如恶性肿瘤或系统性红斑狼疮等潜在疾病的临床证据。对这两名患者及其家庭成员进行了HLA分型。发现两名患者共有几种HLA抗原。然而，在他们两人中均未发现据报道与特发性膜性肾病相关的HLA抗原。
