Domingues Renato, Lippi Alice, Setz Cristian, Outeiro Tiago F, Krisko Anita
Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany.
Center of Excellence for Science and Technology-Integration of Mediterranean Region (STIM), Faculty of Science, University of Split, Split, Croatia.
Aging (Albany NY). 2020 Sep 29;12(18):18778-18789. doi: 10.18632/aging.103989.
Pneumonia outbreak in the city of Wuhan, China, prompted the finding of a novel strain of severe acute respiratory syndrome virus (SARS-CoV-2). Here, we discuss potential long-term consequences of SARS-CoV-2 infection, and its possibility to cause permanent damage to the immune system and the central nervous system. Advanced chronological age is one of the main risk factors for the adverse outcomes of COVID-19, presumably due to immunosenescence and chronic low-grade inflammation, both characteristic of the elderly. The combination of viral infection and chronic inflammation in advanced chronological age might cause multiple detrimental unforeseen consequences for the predisposition and severity of neurodegenerative diseases and needs to be considered so that we can be prepared to deal with future outcomes of the ongoing pandemic.
中国武汉市的肺炎疫情促使人们发现了一种新型严重急性呼吸综合征病毒（SARS-CoV-2）。在此，我们讨论SARS-CoV-2感染可能产生的长期后果，以及其对免疫系统和中枢神经系统造成永久性损害的可能性。高龄是COVID-19不良结局的主要风险因素之一，这可能是由于免疫衰老和慢性低度炎症，而这两者都是老年人的特征。高龄状态下的病毒感染与慢性炎症相结合，可能会对神经退行性疾病的易感性和严重程度造成多种有害的意外后果，需要加以考虑，以便我们能为应对当前大流行的未来后果做好准备。
