Liao Chia-Te, Wu Pei-Chih, Shih Jung-Chang, Cheng Tain-Junn, Wu Wen-Shiann
Division of Cardiovascular Medicine, Chi-Mei Medical Center.
Department of Public Health of Medicine, College of Medicine, National Cheng Kung University.
Medicine (Baltimore). 2020 Sep 25;99(39):e22437. doi: 10.1097/MD.0000000000022437.
Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan in the years 2005 and 2010.We enrolled hypertensive individuals from the datasets of the Longitudinal Health Insurance Database (LHID) in 2005 and 2010 in Taiwan separately. We analyzed the hypertension prevalence, incidence, medication treatment, and associated morbidities. The risks of cardiovascular and cerebrovascular events and all-causes mortalities among the hypertensive individuals were evaluated in 3 years of follow-up.There was an increased prevalence of hypertension but decreased incidence of hypertension in those over 65 from 2005 to 2010. Dyslipidemia was the highest rate of co-morbidity in 2005 and 2010. The most frequent categories of anti-hypertensive agents prescribed was 1 or 2 for both 2005 and 2010. Calcium channel blockers were the most common anti-hypertensive agents prescribed, followed by Angiotensin converting enzyme inhibitors/Angiotensin receptor blockers. After 3 years of follow-up, the risks of coronary artery disease (CAD), cerebrovascular diseases (CVD) as well as death were less in 2010 than in 2005 in Taiwan.Our study showed that hypertension individuals had an increased prevalence, younger age, decreased incidence, increased medication treatment associated with decreased the CAD, CVD, and mortalities in 2010 compared to 2005 in Taiwan.
高血压因其相关的发病率、死亡率以及对社会的经济影响,仍然是一个重要的公共卫生问题。本研究的目的是比较2005年和2010年台湾地区按年龄分层的高血压患病率、发病率、合并症以及三年心血管结局的长期变化。我们分别从2005年和2010年台湾纵向健康保险数据库(LHID)的数据集中纳入高血压患者。我们分析了高血压患病率、发病率、药物治疗及相关合并症。在三年的随访中评估了高血压患者心血管和脑血管事件的风险以及全因死亡率。从2005年到2010年,65岁以上人群中高血压患病率上升但发病率下降。2005年和2010年合并症发生率最高的是血脂异常。2005年和2010年最常开具的抗高血压药物类别均为1种或2种。钙通道阻滞剂是最常用的抗高血压药物,其次是血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂。经过三年随访,2010年台湾地区冠心病(CAD)、脑血管疾病(CVD)以及死亡的风险低于2005年。我们的研究表明,与2005年相比,2010年台湾地区高血压患者患病率上升、年龄更轻、发病率下降、药物治疗增加,同时CAD、CVD及死亡率降低。