Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia; Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, Australia.
University of Ottawa Heart Institute, Ottawa, Canada.
Respir Med. 2020 Nov;173:106161. doi: 10.1016/j.rmed.2020.106161. Epub 2020 Sep 22.
Sarcoidosis is an inflammatory systemic disease that commonly affects the lungs or lymph nodes but can manifest in other organs. Herein, we review the latest evidence establishing how innate and adaptive immune responses contribute to the pathogenesis and clinical course of sarcoidosis. We discuss the possible role of microbial organisms as etiologic agents in sarcoidosis and the evidence supporting sarcoidosis as an autoimmune disease. We also discuss how animal and in vitro human models have advanced our understanding of the immunopathogenesis of sarcoidosis. Finally, we discuss therapeutics for sarcoidosis and the effects on the immune system.
结节病是一种炎症性全身性疾病，通常影响肺部或淋巴结，但也可能表现在其他器官。本文综述了最新证据，确立了先天和适应性免疫反应如何导致结节病的发病机制和临床过程。我们讨论了微生物作为结节病病因的可能作用，以及支持结节病为自身免疫性疾病的证据。我们还讨论了动物和体外人类模型如何促进我们对结节病免疫发病机制的理解。最后，我们讨论了结节病的治疗方法及其对免疫系统的影响。
