Sawyer Abbey, Cavalheri Vinicius, Jenkins Sue, Wood Jamie, Cecins Nola, Bear Natasha, Singh Bhajan, Gucciardi Daniel, Hill Kylie
School of Physiotherapy and Exercise Science, Faculty of Health Science, Curtin University, Kent Street, Bentley, WA 6102, Australia.
Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.
J Clin Med. 2020 Sep 25;9(10):3098. doi: 10.3390/jcm9103098.
To optimize outcomes in people with cystic fibrosis (CF), guidelines recommend 30 to 60 min of moderate-intensity aerobic exercise on most days. Accumulating this volume of exercise contributes importantly to the substantial treatment burden associated with CF. Therefore, the main aim of this study was to investigate the effects of low-volume high-intensity interval training (HIIT) on exercise capacity in people with CF.
This randomized controlled trial included people with CF aged ≥15 years, who were allocated to either eight weeks of thrice-weekly 10-min sessions of HIIT (experimental group) or eight weeks of weekly contact (control group). Before and after the intervention period, participants completed measurements of time to symptom limitation (T) during a constant work rate cycle ergometry test (primary outcome), and maximal work rate (W) during a ramp-based cycle ergometry test and health-related quality of life (HRQoL).
Fourteen participants (median (IQR) age 31 (28, 35) years, forced expiratory volume in 1 second (FEV) 61 (45, 80) % predicted) were included (seven in each group). Compared to the control group, participants in the experimental group demonstrated a greater magnitude of change in T, W ( = 0.017 for both) and in the physical function domain of HRQoL ( = 0.03). No other between-group differences were demonstrated. Mild post-exercise muscle soreness was reported on a single occasion by four participants. Overall, participants attended 93% of all HIIT sessions.
Eight weeks of low-volume (i.e., 30-min/week) HIIT produced gains in exercise capacity and self-reported physical function and was well tolerated by people with CF.
为优化囊性纤维化（CF）患者的治疗效果，指南建议多数日子进行30至60分钟的中等强度有氧运动。累积如此运动量对CF相关的巨大治疗负担有重要影响。因此，本研究的主要目的是调查低量高强度间歇训练（HIIT）对CF患者运动能力的影响。
这项随机对照试验纳入了年龄≥15岁的CF患者，他们被分配到为期八周、每周三次、每次10分钟的HIIT训练组（实验组）或为期八周的每周一次接触组（对照组）。在干预期前后，参与者在恒定工作率的自行车测力计测试中完成症状受限时间（T）的测量（主要结果），在基于斜坡的自行车测力计测试中完成最大工作率（W）的测量以及与健康相关的生活质量（HRQoL）的测量。
纳入了14名参与者（年龄中位数（四分位间距）为31（28，35）岁，第1秒用力呼气量（FEV）为预测值的61（45，80）%）（每组7名）。与对照组相比，实验组的参与者在T、W方面的变化幅度更大（两者均为P = 0.017），在HRQoL的身体功能领域方面变化幅度也更大（P = 0.03）。未显示出其他组间差异。四名参与者曾有一次报告运动后轻度肌肉酸痛。总体而言，参与者参加了所有HIIT课程的93%。
为期八周的低量（即每周30分钟）HIIT训练使运动能力和自我报告的身体功能有所提高，并且CF患者对其耐受性良好。
