Effect of Antibiotic Susceptibility and and Genotype on the Outcome of Vonoprazan-Containing Eradication Therapy.

BACKGROUND

eradication containing the potassium-competitive acid blocker, vonoprazan, achieves a higher eradication rate than therapy with proton pump inhibitors (PPIs). Because vonoprazan is mainly metabolized by CYP3A4/5, CYP genotype may affect the eradication rate. We investigated the influence of antibiotic susceptibility and and genotypes on the eradication rates.

METHODS

A total of 307 Japanese who were genotyped for *1/*22, *1/*3 and *1/*2/*3/*17, and investigated for susceptibility to antimicrobial agents, received vonoprazan-containing regimens: (1) With amoxicillin and clarithromycin as the first-line treatment; (2) with amoxicillin and metronidazole as the second-line treatment; or (3) with amoxicillin and sitafloxacin as the third-line treatment.

RESULTS

The eradication rate was 84.5% (95% confidence interval [CI]: 78.9-89.1%) using first-line, 92.6% (95% CI: 82.1-97.9%) using second-line and 87.5% (95% CI: 73.1-95.8%) using third-line treatment. Infection with clarithromycin-resistant strains was a predictive factor for failed eradication (odds ratio: 5.788, 95% CI: 1.916-17.485, = 0.002) in multivariate analysis. No significant differences were observed in the eradication rate of regimens among , and genotypes.

CONCLUSIONS

Genotyping for *1/*22, *1/*3 and *1/*2/*3/*17 before vonoprazan-containing eradication treatment may not be useful for predicting clinical outcomes.