Jiang Yan, Ji Linhua
Department of Hematology, the Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
Department of Hematology, Huadu District People's Hospital of Guangzhou, Guangzhou, China.
J Int Med Res. 2020 Sep;48(9):300060520959487. doi: 10.1177/0300060520959487.
A 55-year-old woman developed acute promyelocytic leukaemia during treatment with all-trans-retinoic acid and arsenic trioxide. Initially, she presented with symptoms of epigastric pain, vomiting, and nausea, and she developed acute pancreatitis. She was treated with parenteral nutritional supplementation for 20 days. However, the patient continued to develop refractory hyponatraemia, hypotension, and apathy. Finally, the patient was diagnosed with Wernicke encephalopathy (WE) using head magnetic resonance imaging. The patient underwent high-dose intravenous thiamine administration, and her symptoms were alleviated. WE is a rare adverse event during acute pancreatitis therapy. Acute pancreatitis that is caused by all-trans-retinoic acid and arsenic trioxide is a rare complication of acute promyelocytic leukaemia during chemotherapy. Further study is essential to improve our comprehension of the risk factors for complications in patients with acute promyelocytic leukaemia, considering that the associated complications were potentially caused by multiple etiological factors. A better understanding of these risk factors may help to improve the prognosis of patients with acute promyelocytic leukaemia at an early stage.
一名55岁女性在接受全反式维甲酸和三氧化二砷治疗期间发生急性早幼粒细胞白血病。最初，她出现上腹部疼痛、呕吐和恶心症状，并发展为急性胰腺炎。她接受了20天的肠外营养补充治疗。然而，患者继续出现难治性低钠血症、低血压和淡漠。最终，通过头部磁共振成像诊断该患者患有韦尼克脑病（WE）。患者接受了大剂量静脉注射硫胺素治疗，症状得到缓解。WE是急性胰腺炎治疗期间罕见的不良事件。全反式维甲酸和三氧化二砷引起的急性胰腺炎是急性早幼粒细胞白血病化疗期间罕见的并发症。鉴于相关并发症可能由多种病因引起，进一步研究对于提高我们对急性早幼粒细胞白血病患者并发症危险因素的认识至关重要。更好地了解这些危险因素可能有助于改善急性早幼粒细胞白血病患者的早期预后。
