Cardiology, Samsun Education and Research Hospital, Samsun, Turkey.
Cardiology, Samsun Education and Research Hospital, Samsun, Turkey
J Investig Med. 2021 Jan;69(1):20-27. doi: 10.1136/jim-2020-001459. Epub 2020 Sep 29.
Galectin-3 is an inflammation biomarker associated with atrial remodeling which plays a role in the development of atrial fibrillation (AF). Atrial high-rate episode (AHRE) is related to development of clinically documented AF and stroke. The present study aimed to determine the relationship between the presence of AHRE and the coronary sinus (CS) serum sampling of galectin-3 levels in the long-term follow-up of cardiac resynchronization therapy (CRT) patients. A total of 108 consecutive CRT patients were included prospectively in the study. AHREs were defined as atrial tachyarrhythmia episodes lasting at least 6 min with atrial rate >190 beats/min detected by cardiac implantable electronic device. CS blood samples were drawn from the CS guiding catheter to perform galectin-3 measurements. Galectin-3 levels were measured via ELISA. During a mean follow-up 12.6±4.9 months, AHRE was observed in 31 (28.7%) patients and not observed in 77 (72.3%) patients. CS galectin-3 levels were significantly higher in patients with AHRE than those without AHRE (18.09±2.62 vs 13.17±3.17, respectively, p<0.001). Moreover, CS galectin-3 levels showed significant positive correlation with percent of time spent in total AHRE (r=0.436, p<0.001). Multivariate logistic regression analysis demonstrated that left atrium (LA) volume and CS galectin-3 levels were significant and independent predictors for AHRE (OR=1.127, 95% CI: 1.045 to 1.216; p=0.002, OR=1.799, 95% CI: 1.388 to 2.330; p<0.001, respectively). In this study, we determined that high CS galectin-3 levels were a predictor for the development of AHRE in CRT patients.
半乳糖凝集素-3 是一种与心房重构相关的炎症生物标志物，在心房颤动（AF）的发生发展中起作用。心房高频事件（AHRE）与临床确诊的 AF 和中风的发生发展相关。本研究旨在确定长期心脏再同步治疗（CRT）患者冠状窦（CS）血清半乳糖凝集素-3水平与 AHRE 之间的关系。前瞻性纳入了 108 例连续 CRT 患者。AHRE 定义为通过心脏植入式电子设备检测到的持续至少 6 分钟、心房率>190 次/分钟的房性心动过速事件。通过 CS 引导导管抽取 CS 血样进行半乳糖凝集素-3 测量。通过 ELISA 测量半乳糖凝集素-3 水平。在平均 12.6±4.9 个月的随访期间，31 例（28.7%）患者出现 AHRE，77 例（72.3%）患者未出现 AHRE。与无 AHRE 患者相比，有 AHRE 患者的 CS 半乳糖凝集素-3 水平显著更高（18.09±2.62 比 13.17±3.17，p<0.001）。此外，CS 半乳糖凝集素-3 水平与总 AHRE 时间百分比呈显著正相关（r=0.436，p<0.001）。多变量逻辑回归分析表明，左心房（LA）容积和 CS 半乳糖凝集素-3 水平是 AHRE 的显著独立预测因素（OR=1.127，95%CI：1.045 至 1.216；p=0.002，OR=1.799，95%CI：1.388 至 2.330；p<0.001）。在这项研究中，我们确定高 CS 半乳糖凝集素-3 水平是 CRT 患者发生 AHRE 的预测因子。
