Sapru R P, Ganguly N K, Sharma S, Chandani R E, Gupta A K
Br Med J. 1977 Aug 13;2(6084):422-4. doi: 10.1136/bmj.2.6084.422.
Cell-mediated immunity and blood complement activities were studied in 35 patients with chronic rheumatic heart disease (RHD) and 17 normal subjects. The T-cell population in patients with RHD was reduced, as were the CH50 and C3 complement levels. The response to phytohaemagglutinin stimulation was deficient, but the lymphocytes of patients with RHD showed increased avidity for 3H-thymidine when stimulated with specific streptococcal membrane antigen. No differences were found between patients with acute rheumatic activity and those without such activity. The susceptibility of individual patients may be related to the specific sensitisation of lymphocytes, while the fact that this persisted even when T-cell numbers had returned to normal may account for the well-known recrudescenses after streptococcal infections in these patients.
对35例慢性风湿性心脏病（RHD）患者和17名正常受试者的细胞介导免疫和血液补体活性进行了研究。RHD患者的T细胞群体减少，CH50和C3补体水平也降低。对植物血凝素刺激的反应不足，但RHD患者的淋巴细胞在用特异性链球菌膜抗原刺激时对3H-胸腺嘧啶核苷的亲和力增加。急性风湿活动患者和无此类活动患者之间未发现差异。个体患者的易感性可能与淋巴细胞的特异性致敏有关，而即使T细胞数量恢复正常这种情况仍持续存在这一事实，可能解释了这些患者链球菌感染后众所周知的复发情况。
