Sun Yang, Zhu Xiaobo, Hou Junling, Hou Kun, Jin Weiwei
Department of Neurosurgery, No.1 Hospital Branch 2 of Jilin University, Jilin, Changchun, China.
Saudi J Biol Sci. 2020 Oct;27(10):2701-2705. doi: 10.1016/j.sjbs.2020.06.017. Epub 2020 Jun 17.
To explore the clinical effects of mouse Nerve Growth Factor (NGF) in treating cerebral injury in acute period caused by cerebral hemorrhage, observe its influences on Natriuretic Peptide (BNP) and NF-kB Level and evaluate its safety and efficiency.
96 cases with acute cerebral hemorrhage from January 2016 to January 2017 in our hospital were recruited as this study, they were randomly divided into the control group and the observation group, each 48 cases. The observation group were given NGF on the treatment of the control group. NIHSS, BI score, adverse reactions records were compared in two groups before and after treatment. The clinical effective rate were evaluated. Then BNP and NF-KB Level of patients in two groups before and after treatment were detected by using ELISA.
There were no significant differences in two groups before treatment with respect to NIHSS and BI score ( 0.05). After treatment, NIHSS score in the observation group significantly lower than the control group. BI score in the observation group significantly higher than the control group, differences had obvious significance ( 0.05). The total effective rate in the observation group was 93.75%. The control group was 70.83%. Clinical effective rate of patients in the observation group significantly better than the control group ( 0.05). There were no significant differences of patients in two groups before treatment with respect to BNP and NF-kB Level ( 0.05). BNP and NF-kB Level decreased with different levels in two groups after treatment, and the observation group lower than the control group at the same time ( 0.05).
NGF is benefit for relieving neurological function injury of patients with acute cerebral hemorrhage in acute period, improving living ability of patients. Patients have good tolerance and no adverse reactions. NGF can lower BNP and NF-kB Level. It has a certain function of inhibiting inflammatory injury caused by cerebral hemorrhage, thus protecting neuron. It is worthy of clinical promotion.
探讨小鼠神经生长因子（NGF）治疗脑出血急性期脑损伤的临床效果，观察其对脑钠肽（BNP）及核因子-κB（NF-κB）水平的影响，评价其安全性及有效性。
选取2016年1月至2017年1月我院收治的96例急性脑出血患者作为研究对象，随机分为对照组和观察组，每组48例。观察组在对照组治疗基础上加用NGF。比较两组治疗前后美国国立卫生研究院卒中量表（NIHSS）评分、日常生活活动能力（BI）评分及不良反应发生情况，评价临床有效率。采用酶联免疫吸附测定法（ELISA）检测两组患者治疗前后BNP及NF-κB水平。
两组治疗前NIHSS评分及BI评分比较，差异无统计学意义（P>0.05）。治疗后，观察组NIHSS评分显著低于对照组，BI评分显著高于对照组，差异有统计学意义（P<0.05）。观察组总有效率为93.75%，对照组为70.83%，观察组临床有效率显著高于对照组（P<0.05）。两组治疗前BNP及NF-κB水平比较，差异无统计学意义（P>0.05）。治疗后两组BNP及NF-κB水平均有不同程度下降，且观察组低于对照组，差异有统计学意义（P<0.05）。
NGF有助于减轻急性脑出血患者急性期神经功能损伤，提高患者生活能力。患者耐受性良好，无不良反应。NGF可降低BNP及NF-κB水平，具有一定抑制脑出血所致炎症损伤、保护神经元的作用，值得临床推广。
