安坦对精神分裂症患者记忆的影响。

The effect of trihexphenidyl (Artane) on memory in schizophrenic patients.

作者信息

Fennig S, Levine Y, Naisberg S, Elizur A

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(1):71-8. doi: 10.1016/0278-5846(87)90033-9.

DOI:10.1016/0278-5846(87)90033-9

Abstract

The anticholinergic effect of trihexphenidyl on memory function of 20 schizophrenic patients has been investigated in a double blind crossover design. Impairment of immediate memory and short term memory was evident after trihexphenidyl treatment in comparison with placebo. Sensory short term memory tested by visual tasks and remote memory showed no significant statistical differences. Our data suggested that trihexphenidyl due to its anticholinergic effect might impair memory function.

摘要

采用双盲交叉设计，研究了20例精神分裂症患者服用苯海索后对记忆功能的抗胆碱能作用。与安慰剂相比，服用苯海索后即刻记忆和短期记忆明显受损。通过视觉任务测试的感觉性短期记忆和远期记忆无显著统计学差异。我们的数据表明，苯海索因其抗胆碱能作用可能损害记忆功能。

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