接受抗胆碱能治疗的帕金森病患者近期记忆功能障碍。

Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy.

作者信息

Koller W C

出版信息

Cortex. 1984 Jun;20(2):307-11. doi: 10.1016/s0010-9452(84)80051-9.

Abstract

Disruption of cholinergic neurotransmission may result in memory impairment. In this study the anticholinergic drug, trihexyphenidyl, at low doses when administered chronically for one month to Parkinson disease patients caused a decrease in performance on recent but not immediate memory tests. Awareness of possible deterioration of memory function of parkinsonian patients on anticholinergic medication is necessary.

摘要

胆碱能神经传递的中断可能导致记忆障碍。在本研究中，抗胆碱能药物苯海索，以低剂量长期给予帕金森病患者一个月后，导致近期记忆测试的表现下降，但即时记忆测试未受影响。必须意识到帕金森病患者服用抗胆碱能药物时记忆功能可能恶化。