唐氏综合征向阿尔茨海默病临床前期和前驱期转变的认知指标
Cognitive indicators of transition to preclinical and prodromal stages of Alzheimer's disease in Down syndrome.
作者信息
Hartley Sigan L, Handen Benjamin L, Devenny Darlynne, Tudorascu Dana, Piro-Gambetti Brianna, Zammit Matthew D, Laymon Charles M, Klunk William E, Zaman Shahid, Cohen Annie, Christian Bradley T
机构信息
Waisman Center University of Wisconsin-Madison Madison Wisconsin USA.
Department of Human Development & Family Studies University of Wisconsin-Madison Madison Wisconsin USA.
出版信息
Alzheimers Dement (Amst). 2020 Sep 13;12(1):e12096. doi: 10.1002/dad2.12096. eCollection 2020.
INTRODUCTION
There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at-risk population. The objective of the study was to longitudinally track performance on cognitive measures in relation to neocortical and striatal amyloid beta (Aβ) in non-demented Down syndrome.
METHODS
The study included 118 non-demented adults with Down syndrome who participated in two to five points of data collection, spanning 1.5 to 8 years. Episodic memory, visual attention and executive functioning, and motor planning and coordination were assessed. Aβ was measured via [C-11] Pittsburgh Compound-B (PiB) PET.
RESULTS
PiB was associated with level and rate of decline in cognitive performance in episodic memory, visual attention, executive functioning, and visuospatial ability in models controlling for chronological age.
DISCUSSION
The Cued Recall Test emerged as a promising indicator of transition from preclinical to prodromal AD.
引言
迫切需要确定对唐氏综合征早期阿尔茨海默病（AD）病理生理学敏感的认知功能测量方法，以推进该高危人群的临床试验研究。本研究的目的是纵向跟踪非痴呆唐氏综合征患者在认知测量方面的表现与新皮质和纹状体β-淀粉样蛋白（Aβ）的关系。
方法
该研究纳入了118名非痴呆唐氏综合征成年人，他们参与了两到五个数据收集点，时间跨度为1.5至8年。评估了情景记忆、视觉注意力和执行功能，以及运动计划和协调能力。通过[C-11]匹兹堡化合物B（PiB）PET测量Aβ。
结果
在控制实际年龄的模型中，PiB与情景记忆、视觉注意力、执行功能和视觉空间能力的认知表现水平及下降速率相关。
讨论
线索回忆测试成为从临床前AD转变为前驱AD的一个有前景的指标。
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