Bateman Daniel R, Gill Sascha, Hu Sophie, Foster Erin D, Ruthirakuhan Myuri T, Sellek Allis F, Mortby Moyra E, Matušková Veronika, Ng Kok Pin, Tarawneh Rawan M, Freund-Levi Yvonne, Kumar Sanjeev, Gauthier Serge, Rosenberg Paul B, Ferreira de Oliveira Fabricio, Devanand D P, Ballard Clive, Ismail Zahinoor
Department of Psychiatry Indiana University School of Medicine Indianapolis Indiana.
Indiana University Center for Aging Research Regenstrief Institute Indianapolis Indiana.
Alzheimers Dement (N Y). 2020 Sep 6;6(1):e12016. doi: 10.1002/trc2.12016. eCollection 2020.
To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre-dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late-onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre-dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre-dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia.
为了识别在认知障碍或痴呆症发作之前新发激越和冲动方面的知识空白，国际促进阿尔茨海默病研究和治疗神经精神综合征（NPS）专业兴趣领域进行了一项范围综述。在一系列探索痴呆前风险综合征轻度行为损害（MBI）的综述基础上，我们聚焦于迟发性激越和冲动（MBI冲动失控领域）以及认知能力下降和痴呆症的发病风险。这项关于痴呆前综合征激越和冲动的范围综述从流行病学、诊断与测量、神经生物学、神经影像学、生物标志物、病程与预后、治疗以及正在进行的临床试验等方面总结了当前的生物医学文献。需要对诸如MBI清单等痴呆前量表进行验证，并将其纳入纵向和干预试验，以更好地理解冲动失控作为轻度认知障碍和痴呆症风险因素的情况。
