Ghosh A, Poddar R K
Can J Microbiol. 1977 Aug;23(8):1069-77. doi: 10.1139/m77-160.
The synthesis of beta-galactosidase (EC 3.2.1.23;beta-D-galactoside galactohydrolase) in E. coli was repressed as a result of infection with single-stranded DNA phage phi chi 174. Evidence is presented to show that this repression was not due to the restricted entry of the inducer molecules into the infected cells but to some phage-specified product(s). It was further shown that either the infected cells synthesized a fewer number of enzyme-specific mRNA or all such molecules were translated with a reduced efficiency; the half-lives of the mRNA's remained more or less unaffected.
由于受到单链DNA噬菌体φX174的感染，大肠杆菌中β-半乳糖苷酶（EC 3.2.1.23；β-D-半乳糖苷半乳糖水解酶）的合成受到抑制。有证据表明，这种抑制并非由于诱导剂分子进入受感染细胞的受限，而是由于某些噬菌体特定产物。进一步表明，要么受感染细胞合成的酶特异性mRNA数量减少，要么所有这些分子的翻译效率降低；mRNA的半衰期或多或少不受影响。
