Ruiz-Perez L M, Osuna A, Lopez M C, Castanys S, Gammaro F, Craciunescu D, Alonso C
Trop Med Parasitol. 1987 Mar;38(1):45-8.
The trypanocidal activity of three new compounds derived of the antineoplastic drug cis-diamminodichloroplatinum(II) (DDP) has been studied over epimastigote forms of Trypanosoma cruzi. The electron microscopy indicated that, in the treated animals, the nuclear chromatin is distributed in the nucleus in a lax form and that the number of lipidic vacuoles increases largely. This action is more significant when cis-Pt(II)1,2-diaminocyclohexane is used. In addition this compound causes a destabilization of the DNA double helix with a decrease of melting temperature. The three compounds inhibit the incorporation of leucine, uridine and thymidine, although the thymidine uptake is the most significantly affected.
已对三种由抗肿瘤药物顺二氯二氨铂（II）（DDP）衍生的新化合物对克氏锥虫前鞭毛体形式的杀锥虫活性进行了研究。电子显微镜检查表明，在接受治疗的动物中，核染色质以松散的形式分布在细胞核中，并且脂质空泡的数量大量增加。当使用顺铂（II）1,2-二氨基环己烷时，这种作用更为显著。此外，该化合物会导致DNA双螺旋结构不稳定，解链温度降低。这三种化合物均抑制亮氨酸、尿苷和胸苷的掺入，尽管胸苷摄取受到的影响最为显著。
