P.L. Shupyk National Medical Academy of Postgraduate Education, Kyiv 04112, Ukraine.
SI "Institute of Nuclear Medicine and Diagnostic Radiology of National Academy of Medical Science of Ukraine", Kyiv 04050, Ukraine.
Exp Oncol. 2020 Sep;42(3):215-219. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-3.14898.
To evaluate the sensitivity and specificity of digital breast tomosynthesis compared with full-field digital mammography in detection of breast cancer presenting as a mass in women with dense breasts. Маterials and Methods: This study included 347 asymptomatic and symptomatic patients with dense breasts who underwent full-field digital mammography, digital breast tomosynthesis and hand-held full breast ultrasound. 57 core-needle biopsies were performed. Pathology included 31 invasive cancers and 26 non-cancerous lesions.
Sensitivity of full-field digital mammography was 61.3% [0.422-0.789] and sensitivity of digital breast tomosynthesis was 77.4% [0.589-0.904]. Specificity of full-field digital mammography was 92.7% [0.893-0.953] that was 2.2% lower than the specificity of digital breast tomosynthesis - 94.9% [0.919-0.971].
Results of our study showed superior sensitivity and specificity of digital breast tomosynthesis compared to full-field digital mammography for detection of malignant masses in women with dense breasts.
评估数字乳腺断层合成摄影与全数字化乳腺摄影在检测致密乳腺中表现为肿块的乳腺癌的敏感性和特异性。
本研究纳入了 347 例无症状和有症状的致密乳腺患者，均接受全数字化乳腺摄影、数字乳腺断层合成摄影和手持全乳腺超声检查。共进行了 57 例空心针活检。病理学检查包括 31 例浸润性癌和 26 例非癌性病变。
全数字化乳腺摄影的敏感性为 61.3%（0.422-0.789），数字乳腺断层合成摄影的敏感性为 77.4%（0.589-0.904）。全数字化乳腺摄影的特异性为 92.7%（0.893-0.953），比数字乳腺断层合成摄影的特异性低 2.2%，后者为 94.9%（0.919-0.971）。
本研究结果表明，数字乳腺断层合成摄影在检测致密乳腺中恶性肿块方面的敏感性和特异性优于全数字化乳腺摄影。
