基质金属蛋白酶-8 在牙周炎患者唾液和龈沟液中的重要性。

Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients.

机构信息

Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran J Immunol. 2020 Sep;17(3):236-243. doi: 10.22034/iji.2020.81170.1512.

DOI:10.22034/iji.2020.81170.1512

PMID:32996900

Abstract

BACKGROUND

Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis.

OBJECTIVE

To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe chronic periodontitis.

METHODS

42 participants were divided into two groups: a case group (21 patients with generalized moderate to severe chronic periodontitis) and a control group (21 healthy periodontal subjects). GCF and saliva samples were obtained from both groups. Salivary and GCF MMP-8 levels of each subject were detected using the ELISA method.

RESULTS

Mean±SD values of salivary MMP-8 levels of the control and case groups were 1.52 ± 0.65 ng/ml and 6.06 ± 1.18 ng/ml, respectively, and statistically significant difference was observed (p=0.0001). Also, mean±SD values of GCF MMP-8 levels of the control and case groups were 0.87 ± 0.26 ng/ml and 2.92 ± 0.64 ng/ml, respectively; which was statistically significant (p=0.0001).

CONCLUSION

Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group.

摘要

背景

基质金属蛋白酶（MMPs）可刺激慢性牙周炎中的牙槽骨丢失。

目的

评估中重度慢性牙周炎患者的唾液和龈沟液（GCF）中 MMP-8 的水平。

方法

将 42 名参与者分为两组：病例组（21 名患有广泛中重度慢性牙周炎的患者）和对照组（21 名健康牙周受试者）。从两组中获取 GCF 和唾液样本。使用 ELISA 法检测每位受试者的唾液和 GCF MMP-8 水平。

结果

对照组和病例组的唾液 MMP-8 水平的平均值±标准差分别为 1.52 ± 0.65ng/ml 和 6.06 ± 1.18ng/ml，差异具有统计学意义（p=0.0001）。同样，对照组和病例组的 GCF MMP-8 水平的平均值±标准差分别为 0.87 ± 0.26ng/ml 和 2.92 ± 0.64ng/ml，差异具有统计学意义（p=0.0001）。