Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA, United States.
Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, MD, United States.
Ann Anat. 2021 Jan;233:151587. doi: 10.1016/j.aanat.2020.151587. Epub 2020 Sep 28.
Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model.
动物研究对于生物医学研究至关重要，而可重现的动物模型则是其基石。虽然有许多关于啮齿动物周围神经损伤模型的报道，但大型动物模型对于确认神经再生效果至关重要，因为人类需要更长的神经再生距离。猪一直被用作其他外科和生物医学研究的大型动物模型。本文代表了一种新的苏塞克斯猪（美国约克夏猪）的神经血管损伤模型。本文将描述我们在术前、术中和术后方案方面的经验和建议，以及我们对这些方案的改进，以产生有效的模型。
