Rheumatology Unit, P. Dettori Hospital, AST Sardegna, Tempio Pausania, Italy.
Rheumatology Unit, University of Messina, Messina, Italy.
Pharmacol Res. 2020 Nov;161:105206. doi: 10.1016/j.phrs.2020.105206. Epub 2020 Sep 28.
Inflammatory bowel disease (IBDs), including the two main subtypes of Crohn's disease and ulcerative colitis, not only affects the gastrointestinal system, but also has a wide range of extra-intestinal manifestations (EIMs) that are major sources of morbidity and disability, and therefore represent what can be considered a real syndrome. The pathogenetic mechanisms underlying these EIMs are unknown, but some may share a common pathogenesis with IBD and others may be due to IBD treatment. The aim of this review is to examine our current knowledge of IBD EIMs and their treatment.
炎症性肠病（IBDs），包括克罗恩病和溃疡性结肠炎这两种主要亚型，不仅影响胃肠道系统，而且还具有广泛的肠外表现（EIMs），这些表现是发病率和残疾的主要原因，因此可以被认为是一种真正的综合征。这些 EIMs 的发病机制尚不清楚，但有些可能与 IBD 具有共同的发病机制，而其他则可能是由于 IBD 治疗引起的。本文的目的是检查我们目前对 IBD EIMs 及其治疗的认识。
