Henderson A, Simon J W, Melia W
Trans R Soc Trop Med Hyg. 1986;80(5):838-40. doi: 10.1016/0035-9203(86)90398-6.
Proguanil 200 mg daily and chloroquine base 300 mg weekly were used as prophylaxis for 120 British Army soldiers from Hong Kong on a seven-week jungle exercise in the highly malarious Sepik district of Papua New Guinea. Compliance was rigidly enforced. Four men developed falciparum malaria whilst in Papua New Guinea and one within a few days of returning to Hong Kong. After stopping chloroquine four weeks after returning to Hong Kong 11 cases of mixed vivax and falciparum malaria and three cases of falciparum alone occurred within a 16-week period. This proguanil-chloroquine combination allows an unacceptably high level of breakthrough malaria and cannot be recommended for visitors to the highly malarious areas of Papua New Guinea.
对来自香港的120名英国陆军士兵，在巴布亚新几内亚疟疾高发的塞皮克地区进行为期7周的丛林演习期间，采用每日服用200毫克氯胍和每周服用300毫克氯喹碱基进行预防。严格执行依从性要求。4名士兵在巴布亚新几内亚期间感染恶性疟原虫疟疾，1名在返回香港几天后发病。返回香港4周后停用氯喹，在16周内出现11例间日疟原虫和恶性疟原虫混合感染病例以及3例单纯恶性疟原虫感染病例。这种氯胍 - 氯喹组合导致疟疾突破率高得令人无法接受，不推荐前往巴布亚新几内亚疟疾高发地区的游客使用。
