Ikeda Hiroaki, Takamoto Ayane, Ikeda Junko, Kohno Kiyotaka, Nakatsuma Akira, Tokumura Tadakazu, Mori Kumiko, Iihara Naomi, Houchi Hitoshi, Ninomiya Masaki
Department of Pharmaceutical Health Care and Sciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
Towany Pharmacy.
Yakugaku Zasshi. 2020 Dec 1;140(12):1455-1462. doi: 10.1248/yakushi.20-00136. Epub 2020 Sep 29.
We investigated the success rates of eyedrop instillation and the distance between the cornea and the dropper tip in 100 volunteers using high-speed digital video recording. Past eyedrop adherence studies assumed that instillation occurred without failure. The ideal distance between the cornea and dropper tip remained unclear, although the general estimate was approximately 2.54 cm (1 inch). This study was approved by the Institutional Review Boards of all participating medical institutions, and all volunteers provided written, informed consent. Successful instillation was defined as when 1 drop fell accurately into the eye on the first attempt. The instillation of ≥2 drops or drops delivered outside the eye was considered a failure. The distance between the eye and dropper tip was measured using still images from a paused digital video camera and a digital ruler. Forty percent of the volunteers instilled eyedrops without instructions from ophthalmologists, pharmacists, or other healthcare workers. When the images were analyzed, the success rate of the first instillation was 70.1%. When the eye was arbitrarily divided into 9 sections, most of the drop sites were the iris or the center of the eye. The distance between the dropper tip and cornea was 2.62±1.75 (median 2.20) cm. These results indicate that the generally recommended distance is usually followed. The successful instillation rate based on the distance from the dropper tip to the cornea was 77% at 1.6±0.88 cm and 54.9% at 4.8±1.25 cm.
我们使用高速数字视频记录，对100名志愿者滴眼剂滴入的成功率以及角膜与滴管尖端之间的距离进行了调查。以往的滴眼剂附着研究假定滴入过程不会失败。尽管一般估计角膜与滴管尖端之间的理想距离约为2.54厘米（1英寸），但仍不明确。本研究得到了所有参与医疗机构的机构审查委员会的批准，所有志愿者均提供了书面知情同意书。成功滴入定义为首次尝试时1滴准确落入眼内。滴入≥2滴或滴到眼外被视为失败。使用暂停的数字摄像机拍摄的静止图像和数字标尺测量眼睛与滴管尖端之间的距离。40%的志愿者在没有眼科医生、药剂师或其他医护人员指导的情况下滴入滴眼剂。分析图像时，首次滴入的成功率为70.1%。当将眼睛任意分为9个区域时，大多数液滴落点在虹膜或眼中心。滴管尖端与角膜之间的距离为2.62±1.75（中位数2.20）厘米。这些结果表明，通常遵循了普遍推荐的距离。基于滴管尖端到角膜的距离，在1.6±0.88厘米处成功滴入率为77%，在4.8±1.25厘米处为54.9%。
