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布鲁菌病:210 例不同临床特征病例的评估。

Brucellosis: Evaluation of Two Hundred and Ten Cases with Different Clinical Features.

机构信息

Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey.

出版信息

Ann Acad Med Singap. 2020 Jul;49(7):462-467.

Abstract

INTRODUCTION

Brucellosis is an important zoonotic disease and a major cause of morbidity worldwide presenting with varying clinical manifestations. We aimed to investigate the epidemiological characteristics and complications of brucellosis at the Van Training and Research Hospital from January 2018 to December 2018.

MATERIALS AND METHODS

210 patients with brucellosis were assessed retrospectively. The clinical histories and signs, laboratory findings, therapeutic features and complications of these patients were obtained by examining their medical files.

RESULTS

Of the 210 patients;, the most common symptoms were myalgia (87.6%), arthralgia (76.2%) and fever (72.4%). The most frequent clinical signs were fever (72.4%) and arthritis (21.9%). Out of 210 patients, standard tube agglutination (STA) tests were positive in 208 (99%). Osteoarticular involvement (34.3%) was common, and a combination of rifampicin and doxycycline was the most frequently used antimicrobial regimen.

CONCLUSION

It should be kept in mind that brucellosis may occur in patients presenting with fever, sweating, arthralgia and leukopenia, especially in endemic areas where dairy livestock is prevalent. People living in these areas should be educated about proper animal care and the handling of dairy products.

摘要

简介

布鲁氏菌病是一种重要的人畜共患疾病,也是全球发病率较高的主要病因,具有不同的临床表现。本研究旨在调查 2018 年 1 月至 12 月凡湖培训与研究医院布鲁氏菌病的流行病学特征和并发症。

材料与方法

回顾性评估了 210 例布鲁氏菌病患者。通过查阅病历,获得了这些患者的临床病史和体征、实验室检查结果、治疗特点和并发症。

结果

210 例患者中,最常见的症状是肌痛(87.6%)、关节炎(76.2%)和发热(72.4%)。最常见的临床体征是发热(72.4%)和关节炎(21.9%)。210 例患者中,标准试管凝集(STA)试验阳性 208 例(99%)。骨关节炎受累(34.3%)常见,利福平联合多西环素是最常用的抗菌方案。

结论

应该记住,布鲁氏菌病可能发生在发热、出汗、关节炎和白细胞减少的患者中,特别是在流行地区,那里有奶制品牲畜。应该对生活在这些地区的人们进行有关适当动物护理和奶制品处理的教育。

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